A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs
A Single-Vector, Single-Injection Trivalent Filovirus Vaccine: Proof of Concept Study in Outbred Guinea Pigs
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DOI：
10.1093/infdis/jiv126
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发表时间：
2015-10-01
影响因子：
6.4
通讯作者：
Connor, John H.
中科院分区：
文献类型：
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作者：
Mire, Chad E.;Geisbert, Joan B.;Connor, John H.
丝状病毒，即马尔堡马尔堡病毒（MARV）、扎伊尔埃博拉病毒（ZEBOV）和苏丹埃博拉病毒（SEBOV），在人类和非人灵长类动物（NHP）中引起严重且通常致命的出血热。基于单价重组水疱性口炎病毒（rVSV）的疫苗载体（编码丝状病毒糖蛋白（GP）代替VSV糖蛋白）在啮齿动物和NHP研究中显示出对同源丝状病毒攻毒的100%有效性。在此，我们检查了表达MARV、ZEBOV和SEBOV GP的单载体、单次注射三价rVSV载体在远交哈特利豚鼠中保护免受MARV、ZEBOV和SEBOV诱导的疾病的效用，其中我们观察到保护免受所有3种丝状病毒的影响。
The filoviruses, Marburg marburgvirus (MARV), Zaire ebolavirus (ZEBOV), and Sudan ebolavirus (SEBOV), cause severe and often fatal hemorrhagic fever in humans and nonhuman primates (NHPs). Monovalent recombinant vesicular stomatitis virus (rVSV)-based vaccine vectors, which encode a filovirus glycoprotein (GP) in place of the VSV glycoprotein, have shown 100% efficacy against homologous filovirus challenge in rodent and NHP studies. Here, we examined the utility of a single-vector, single-injection trivalent rVSV vector expressing MARV, ZEBOV, and SEBOV GPs to protect against MARV-, ZEBOV-, and SEBOV-induced disease in outbred Hartley guinea pigs where we observed protection from effects of all 3 filoviruses.