Electrotonic profile and passive propagation of synaptic potentials in three subpopulations of hippocampal CA1 interneurons
Electrotonic profile and passive propagation of synaptic potentials in three subpopulations of hippocampal CA1 interneurons
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DOI：
10.1016/s0306-4522(01)00136-1
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发表时间：
2001-01-01
期刊：
影响因子：
3.3
通讯作者：
Freund, TF
中科院分区：
文献类型：
--
作者：
Emri, ZS;Antal, K;Freund, TF
为了阐明树突形态在信号传递中的作用，在CA 1区的三个中间神经元亚群的多室模型中比较了体细胞和树突电位的被动传播。9钙结合蛋白，15钙视网膜蛋白和10小清蛋白含有细胞建模，将详细的几何形状。索马中的动作电位电流和树突中AMPA、N-甲基-D-天冬氨酸和GABA-B受体介导的突触后电流。电缆的性能表现出不同的亚群之间的特征差异。Calbindin和Calretinin细胞树突的形态长度大于小清蛋白细胞。因此，小白蛋白细胞比钙结合蛋白或钙视网膜蛋白细胞更紧凑，除非它们的轴向和膜的比超过其他两种细胞类型的比超过33%。在钙结合蛋白细胞中，侵入肺泡的极长树突的远端部分实际上与索马体隔离，用于被动传播信号。在给定的morphonic距离诱发的突触电位从索马显示出较大的差异，局部树突上的索马在所有的亚群。PV细胞的体细胞和树突细胞的振幅比最小。在calbindin细胞中，在离索马相同的morphonic距离处诱发的突触电位的躯体振幅是相似的，而不管其路径沿着的分支点的数量。在calretinin和parvalbumin细胞中，从具有长初级节段的树突到达索马的突触电位的幅度比从靠近索马分支的树突更大。对体细胞膜电位影响较大的树突通常是进入腔隙-分子层的树突，这些结果表明树突的形态改变了不同树突部位诱发的突触电位的有效性，从而可能是决定不同神经元群体整合特性的一个重要因素。FC，（C）2001 IBRO，Elsevier Science Ltd出版，版权所有.
To elucidate the role of dendritic morphology in signal transfer, the passive propagation of somatic and dendritic potentials was compared in multi-compartment models of three interneuron subpopulations in the CA1 region. Nine calbindin, 15 calretinin- and 10 parvalbumin-containing cells were modelled incorporating the detailed geometry. the currents of the action potentials in the soma, and the AMPA, N-methyl-D-aspartate and GABA-B receptor-mediated postsynaptic currents in the dendrites. The cable properties show characteristic differences among the subpopulations. The morphotonic length of calbindin and calretinin cell dendrites is larger than of parvalbumin cells. Thus parvalbumin cells are more compact than calbindin or calretinin cells unless the ratio of their axial and membrane resistivities exceeds the ratios of the other two cell types by more than 33%. In calbindin cells, the distal parts of the extremely long dendrites that invade the alveus are virtually isolated from the soma for passively propagating signals. The synaptic potentials evoked at a given morphotonic distance from the soma show larger differences locally on the dendrites than on the soma in all subpopulations. Both the somatic and dendritic amplitude ratios are the smallest in PV cells. In calbindin cells the somatic amplitude of synaptic potentials evoked at the same morphotonic distance from the soma is similar regardless of the number of branchpoints along their path. In calretinin and parvalbumin cells, from dendrites with long primary segments synaptic potentials reach the soma with larger amplitude than from dendrites that are branching close to the soma. The dendrites with the larger impact on somatic membrane potential are usually the dendrites that enter the stratum lacunosum-moleculare.These results indicate that dendritic morphology plays a role in changing the effectiveness of synaptic potentials evoked at different dendritic locations, and in this way is likely to be an important factor in determining the integrative properties of the different neuron populations. FC, (C) 2001 IBRO, Published by Elsevier Science Ltd, All rights reserved.