The effect of systemic hydration on normal and impaired mucociliary function.
The effect of systemic hydration on normal and impaired mucociliary function.
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全身水合对正常和受损的粘膜纤毛功能的影响。
DOI：
10.1002/ppul.1950010209
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发表时间：
1985
影响因子：
3.1
通讯作者：
Wanner,A
中科院分区：
文献类型：
--
作者：
Marchette,LC;Marchette,BE;Abraham,WM;Wanner,A
研究了全身水合作用是否增强正常肺和抗原诱导的支气管阻塞期间肺中下气道分泌物的清除。在5只清醒的过敏性绵羊中，在静脉输注体积范围为5至35 ml/kg的5%葡萄糖溶液之前和之后连续60分钟测量气管粘液流速（TMV）作为下气道粘膜纤毛清除率的指标。这些液体方案对TMV均无显著影响，尽管在25和35 ml/kg的较高体积下有减缓TMV的趋势。在通过吸入特异性抗原激发产生急性过敏性气道反应后，在假输注和输注35 ml/kg葡萄糖溶液前，平均TMV分别降低27%和15%。在随后的60分钟观察期内，葡萄糖输注进一步损害了粘膜纤毛转运，在所有测量时间点，葡萄糖输注后的平均TMV均低于假输注后（P< 0.05）。葡萄糖输注后30分钟达到最低值（对照的45%）。得出的结论是，全身水合作用并不显着改变气道黏膜纤毛运输在正常状态下，但进一步损害黏膜纤毛运输在过敏性黏膜纤毛功能障碍。这就提出了关于全身水合作用在治疗儿童和成人支气管哮喘中的治疗作用的问题。
Whether systemic hydration enhances the clearance of lower airway secretions in normal lungs and in lungs during antigen‐induced bronchial obstruction was studied. In five conscious allergic sheep, tracheal mucus velocity (TMV) as an index of lower airway mucociliary clearance was measured before and serially for 60 minutes following intravenous infusion of 5% dextrose solution at volumes ranging from 5 to 35 ml/kg. None of these fluid regimens had a significant effect on TMV, although there was a tendency toward a slowing of TMV at the higher volumes of 25 and 35 ml/kg. After producing an acute allergic airway response by inhalation challenge with specific antigen, there was a decrease in mean TMV by 27% and 15% before sham infusion and infusion of 35 ml/kg of dextrose solution, respectively. During the subsequent 60‐minute observation period, mucociliary transport was further impaired by dextrose infusion, with mean TMV being lower after dextrose infusion than after sham infusion at all times of measurement (P< 0.05). The lowest value was reached 30 minutes after dextrose infusion (45% of control). It was concluded that systemic hydration does not significantly alter airway mucociliary transport in the normal state but further impairs mucociliary transport during allergic mucociliary dysfunction. This raises questions regarding the therapeutic role of systemic hydration in the treatment of children and adults who have bronchial asthma.