Alzheimer's disease: progress in prediction.
Alzheimer's disease: progress in prediction.
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DOI：
10.1016/s1474-4422(09)70330-8
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发表时间：
2010-01
期刊：
影响因子：
48
通讯作者：
Petersen, Ronald C.
中科院分区：
文献类型：
--
作者：
Petersen, Ronald C.
在过去的几年里，已经启动了几项旨在预测谁会患上阿尔茨海默病(AD)的重大研究，最终目标是提供一个通过疾病修饰疗法进行治疗干预的平台。其中许多研究旨在评估神经成像和化学生物标记物在评估和预测非认知障碍个人和轻度认知障碍(MCI)患者进展方面的作用。MCI是一种中间临床状态，即个人的获得性记忆障碍超出其年龄预期，但不符合痴呆症的诊断标准。
In the past few years, several major studies have been initiated that have aimed to predict who will develop Alzheimer's disease (AD), with the ultimate goal of providing a platform for therapeutic intervention with disease-modifying therapies. Many of these studies were designed to evaluate the role of neuroimaging and chemical biomarkers in assessing and predicting progression in individuals without cognitive impairment and in individuals with mild cognitive impairment (MCI)—the intermediate clinical state in which individuals have an acquired memory impairment beyond what would be expected for their age, yet do not meet the criteria for a diagnosis of dementia.