Adaptive immunity in invertebrates: a straw house without a mechanistic foundation
Adaptive immunity in invertebrates: a straw house without a mechanistic foundation
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DOI：
10.1002/bies.20650
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发表时间：
2007-11-01
期刊：
影响因子：
4
通讯作者：
Smith, Valerie J.
中科院分区：
文献类型：
--
作者：
Hauton, Chris;Smith, Valerie J.
最近，在无脊椎动物免疫学领域，涉及记忆、特异性和/或免疫活性的母体转移的激进的新见解已被提出。这些主张的证据依赖于在整个有机体水平上观察到的现象，如生存或生殖能力。这些显然具有启发性的假说的吸引力在于，它们与先天免疫的既定观点相反。他们把有颌脊椎动物的适应性反应含蓄地类比起来，使用的术语造成了一种不完整和误导性的画面。我们认为，无脊椎动物的适应性免疫仅基于这种现象的情况下是薄弱和有缺陷的，因为它只能支持，如果支持的基本机制的描述。我们警告不要依赖这种方法作为推进这一领域的手段，例如，强调采用这种方法的一些负面商业影响。
Recently claims have been made for radical new insights in the field of invertebrate immunology that involve memory, specificity and/or maternal transfer of immunocompetence. For evidence these claims rely on phenomena, such as survival or reproductive capacity, observed at the level of the whole organism. The allure of these apparently revelatory hypotheses is that they are contrary to established views of innate immunity. They draw implicit analogy to adaptive responses in jawed vertebrates and the terminology used creates an incomplete and misleading picture. We argue that the case for adaptive immunity in invertebrates based only on such phenomena is weak and flawed, as it can only be upheld if supported by descriptions of the underlying mechanisms. We caution against a reliance on this approach as a means of advancing this field-highlighting, as an example, some negative commercial implications of adopting this approach.