Higher clearance of hepatitis C virus infection in females compared with males
Higher clearance of hepatitis C virus infection in females compared with males
复制标题
DOI：
10.1136/gut.2005.078147
复制
发表时间：
2006-08-01
期刊：
影响因子：
24.5
通讯作者：
Fontanet, A.
中科院分区：
文献类型：
--
作者：
Bakr, I.;Rekacewicz, C.;Fontanet, A.
背景和目的：根据文献，14 - 46%的受试者在感染后从血液中清除了丙型肝炎病毒（HCV）。存在争议的性别差异在HCV清除率rate.Patients和方法：我们比较了男性和女性的HCV清除率从一个大的人口为基础的研究在埃及的HCV感染的数据。本文中使用的定义为：清除的HCV感染（HCV抗体阳性和HCV RNA检测结果阴性）和慢性HCV感染（HCV抗体阳性和HCV RNA检测结果阳性）。结果：4720名18 ~ 65岁农村居民中HCV抗体阳性率为910/4720（19.3%，95%可信区间为18.2 ~ 20.4）。在HCV抗体阳性者（n = 910）中，61.5%有慢性HCV感染。与男性相比，女性更有可能清除病毒（分别为44.6%和33.7%; p = 0.001）。控制年龄，血吸虫病史，医源性暴露，性暴露于HCV没有改变女性性别和病毒clearance.Conclusion之间的正相关性：这项研究提供了有力的证据，有利于更高的HCV清除率在女性与男性相比。
Background and aims: According to the literature, 14 - 46% of subjects clear hepatitis C virus (HCV) from blood after infection. Controversy exists about sex differences in HCV clearance rates.Patients and methods: We compared HCV clearance in males and females using data from a large population based study on HCV infection in Egypt. Definitions used in the paper were: cleared HCV infection (positive HCV antibody and negative HCV RNA test results) and chronic HCV infection (positive HCV antibody and positive HCV RNA test results). The study sample included 4720 village residents aged 18 - 65 years recruited through home based visits (n = 2425) or voluntary screening (n = 2295).Results: Overall, HCV antibody prevalence was 910/4720 (19.3% (95% confidence interval 18.2 - 20.4)). Of those with HCV antibodies (n = 910), 61.5% had chronic HCV infection. Compared with males, females were more likely to have cleared the virus (44.6% v 33.7%, respectively; p = 0.001). Control for age, schistosomiasis history, iatrogenic exposures, and sexual exposure to HCV did not alter the positive association between female sex and viral clearance.Conclusion: This study provides strong evidence in favour of a higher HCV clearance rate in females compared with males.