BODY-WEIGHT CHANGE, ALL-CAUSE MORTALITY, AND CAUSE-SPECIFIC MORTALITY IN THE MULTIPLE RISK FACTOR INTERVENTION TRIAL
BODY-WEIGHT CHANGE, ALL-CAUSE MORTALITY, AND CAUSE-SPECIFIC MORTALITY IN THE MULTIPLE RISK FACTOR INTERVENTION TRIAL
复制标题
DOI：
10.7326/0003-4819-119-7_part_2-199310011-00024
复制
发表时间：
1993-10-01
影响因子：
39.2
通讯作者：
LISSNER, L
中科院分区：
文献类型：
--
作者：
BLAIR, SN;SHATEN, J;LISSNER, L
目的：评价参与多危险因素干预试验(MRFIT)的高危中年男性的体重变异性与死亡的关系。设计：队列研究，随访3.8年。在美国22个临床中心进行的多中心协作一级预防试验。参与者：男性(n=10529)，他们的基线年龄在35岁到57岁之间，他们因吸烟、高血压和胆固醇水平升高而处于冠心病风险的10%到15%之间。参与者至少每年在研究临床中心接受为期6到7年的医学评估。结果：体重变异性的主要衡量标准是体重的个人标准差(ISD)，这是根据6-7年就诊时测量的体重计算得出的。在ISD四分位数中，每1000人年随访的全因死亡率分别为8.28、8.25、10.57和11.07。在调整了与体重变化相关的基线风险因素后，与第一个四分位数相比，第四个四分位数的全因死亡率的相对风险为1.64(95%可信区间为1.21至2.23)。心血管死亡和ISD表现出类似的模式。体重变化与死亡之间的关系在最重的男性中没有观察到。结论：在某些类型的高危男性中，体重变异性越大，心血管疾病和全因死亡率的风险就越大。
Objective: To evaluate the relation between weight variability and death in high-risk, middle-aged men participating in the Multiple Risk Factor Intervention Trial (MRFIT).Design: Cohort study with 3.8 years of follow-up.Setting. Multicenter, collaborative, primary prevention trial conducted at 22 clinical centers in the United States.Participants: Men (n = 10 529) who were 35 to 57 years old at baseline and who were in the upper 10% to 15% of risk for coronary heart disease because of smoking, high blood pressure, and elevated cholesterol level. Participants were seen at least annually for 6 to 7 years for medical evaluations in study clinical centers.Measurements. Death from cardiovascular disease (228 deaths) and from all causes (380 deaths).Results: The primary measure of weight variability was the intrapersonal standard deviation of weight (ISD), which was calculated from measured weights obtained at clinic visits during a 6- to 7-year period. All-cause death rates per 1000 person-years of follow-up across ISD quartiles were 8.28, 8.25,10.57, and 11.07 from the first to fourth quartiles, respectively. After adjusting for baseline risk factors associated with weight change, the relative risk for all-cause mortality in the fourth, compared with the first quartile was 1.64 (95% CI, 1.21 to 2.23). Cardiovascular death and ISD showed a similar pattern. The association between weight change and death was not observed in the heaviest men.Conclusion: Greater weight variability was associated with a greater risk for cardiovascular disease and all-cause mortality in some types of high-risk men.