Distribution, proliferation, and function of Paneth cells in uncomplicated and complicated adult celiac disease
Distribution, proliferation, and function of Paneth cells in uncomplicated and complicated adult celiac disease
复制标题
DOI：
10.1309/5adnar4vn11ttkq6
复制
发表时间：
2008-07-01
影响因子：
3.5
通讯作者：
Corazza, Gino R.
中科院分区：
文献类型：
--
作者：
Di Sabatino, Antonio;Miceli, Emanuela;Corazza, Gino R.
潘氏细胞是位于小肠隐窝底部的颗粒状上皮细胞，在先天免疫中起着至关重要的作用。由于关于潘氏细胞的数量和功能在乳糜泻（CD）中仍然存在争议，我们定量了28例无并发症CD患者、8例并发症CD患者（3例溃疡性空肠结肠炎、2例难治性口炎和3例肠病相关T细胞淋巴瘤）和14例对照组的潘氏细胞和人α-防御素（HD）-5和HD-6。潘氏细胞的数量和增殖没有显着差异，在简单的未经治疗和治疗的CD和对照病例。而复杂型CD的潘氏细胞数量明显减少。在无并发症的未治疗和治疗CD和对照病例中，黏蛋白HD-5和HD-6相当。经处理的CD活检标本的离体麦胶蛋白激发对粘膜HD-5和HD-6转录物没有影响。在单纯性CD中，粘膜中的潘氏细胞数量和α-防御素没有变化。需要进一步的研究来阐明复杂CD中潘氏细胞数量减少的意义。
Paneth cells, granulated epithelial cells located at the base of small bowel crypts, have a crucial role in innate immunity. Because controversies remain concerning Paneth cell numbers and function in celiac disease (CD), we quantified Paneth cells and human alpha-defensin (HD)-5 and HD-6 in 28 patients with uncomplicated CD, 8 patients with complicated CD (3 with ulcerative jejunoileitis, 2 with refractory sprue, and 3 with enteropathy-associated T-cell lymphoma), and 14 control subjects. Paneth cell numbers and proliferation did not differ in uncomplicated untreated and treated CD and control cases. However, the number of Paneth cells was significantly reduced of in complicated CD. Mucosal HD-5 and HD-6 were comparable in uncomplicated untreated and treated CD and control cases. Ex vivo gliadin challenge of treated CD biopsy specimens had no effect on mucosal HD-5 and HD-6 transcripts. Paneth cell numbers and alpha-defensins are unchanged in the mucosa in uncomplicated CD. Further studies are needed to clarify the implications of reduction of numbers of Paneth cells in complicated CD.