Integrative analyses reveal biological function and prognostic role of m7G methylation regulators in high-grade glioma.
Integrative analyses reveal biological function and prognostic role of m7G methylation regulators in high-grade glioma.
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综合分析揭示了M7G甲基化调节剂在高级神经胶质瘤中的生物学功能和预后作用。
DOI：
10.18632/aging.204999
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发表时间：
2023-09-06
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影响因子：
--
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中科院分区：
文献类型：
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基于 29 个 m7G 调节因子，使用中国神经胶质瘤基因组图谱 (CGGA) 和癌症基因组图谱 (TCGA) 数据集的数据将神经胶质瘤患者分为三组。每种神经胶质瘤亚型在免疫细胞浸润、功能富集和临床预后方面观察到独特的特征。分析差异表达基因 (DEG) 证实了三个 m7G 簇之间的区别。开发并证实了一种高级别神经胶质瘤患者总生存期 (OS) 的预测工具，由形成预后特征的 13 个 m7G 调节因子组成。研究发现，m7G 水平升高与肿瘤突变负荷增加和免疫激活相关，表明肿瘤微环境以炎症为特征，总体生存率较低。相比之下，m7G 评分降低与免疫浸润缺陷、突变负担低和非炎症表型有关，这表明临床前景更为积极。此外，m7G 风险评分被发现会影响化疗敏感性。 m7G 预测模式显示出作为高级别神经胶质瘤患者总体生存标记的潜力。通过显着提高我们对 m7G 调节因子在神经胶质瘤进展中的功能作用及其对临床结果影响的理解，这项研究为高级别神经胶质瘤的精准治疗提供了宝贵的视角。
Based on 29 m7G regulators, glioma patients were categorized into three groups using data from the Chinese Glioma Genome Atlas (CGGA) and The Cancer Genome Atlas (TCGA) datasets. Distinct characteristics were observed in immune cell infiltration, functional enrichment, and clinical prognosis for every glioma subtype. Analyzing the differentially expressed genes (DEGs) confirmed the distinction among the three m7G clusters. A predictive tool for overall survival (OS) in high-grade glioma patients was developed and confirmed, consisting of 13 m7G regulators forming a prognostic signature. Elevated m7G levels were found to be associated with increased tumor mutation burden and immune activation, indicating a tumor microenvironment characterized by inflammation and a lower overall survival rate. In contrast, reduced m7G scores were linked to a deficiency in immune infiltration, a low burden of mutations, and a non-inflamed phenotype, suggesting a more positive clinical outlook. Additionally, the m7G risk scores were found to impact chemotherapy sensitivity. The m7G predictive pattern shows potential as a marker for the overall survival of patients with high-grade glioma. By significantly improving our comprehension of the functional role of m7G regulators in the advancement of glioma and their impact on clinical results, this study offers valuable perspectives for precision therapy in the management of high-grade glioma.
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影响因子：
28.5
作者：
通讯作者：
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DOI：
10.4172/1948-5956.1000543
发表时间：
2018
期刊：
Journal of cancer science & therapy
影响因子：
--
作者：
Filippova N;Yang X;An Z;Nabors LB;Pereboeva L
通讯作者：
Pereboeva L
DOI：
10.1007/978-3-031-23705-8_1
发表时间：
2023-01-01
期刊：
HUMAN BRAIN AND SPINAL CORD TUMORS-FROM BENCH TO BEDSIDE, VOL. 2
影响因子：
--
作者：
Wang, Linda M.;Englander, Zachary K.;Bruce, Jeffrey N.
通讯作者：
Bruce, Jeffrey N.
影响因子：
3
作者：
通讯作者：
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影响因子：
3.7
作者：
Wang, Guangyao;Zhao, Mei;Li, Jiao;Li, Guosheng;Zheng, Fukui;Xu, Guanglan;Hong, Xiaohua
通讯作者：
Hong, Xiaohua