Pulmonary Function and Quality of Life in Adults with Cystic Fibrosis.
Pulmonary Function and Quality of Life in Adults with Cystic Fibrosis.
复制标题
囊性纤维化成人的肺功能和生活质量。
DOI：
10.1007/s00408-023-00658-y
复制
发表时间：
2023
期刊：
影响因子：
5
通讯作者：
Kavalieratos,Dio
中科院分区：
文献类型：
--
作者：
Smirnova,Natalia;Lowers,Jane;Magee,MatthewJ;Auld,SaraC;Hunt,WilliamR;Fitzpatrick,Anne;Lama,Vibha;Kavalieratos,Dio
PurposePeople living with cystic fibrosis (CF) experience impaired quality of life, but the extent to which pulmonary function is associated with quality of life in CF remains unclearMethodsUsing baseline data from a trial of specialist palliative care in adults with CF, we examined the association between pulmonary obstruction and quality of life (measured with the Functional Assessment of Chronic Illness Therapy Total Score).ResultsAmong 262 participants, median age was 33, and 78% were on modulator therapy. The median quality of life score was higher in those with mild obstruction (135, IQR 110–156) compared to moderate (125, IQR 109–146) and severe obstruction (120, IQR 106–136). In an unadjusted model, we observed a non-significant trend toward lower quality of life with increased obstruction—compared to participants with mild obstruction, those with moderate obstruction had quality of life score 7.46 points lower (95% CI -15.03 to 0.10) and those with severe obstruction had a score 9.98 points lower (95% CI -21.76 to 1.80). However, this association was no longer statistically significant in the adjusted model, which may reflect confounding due to sex, age, BMI, and modulator therapy. Comorbidities (depression and anxiety) and social determinants of health (financial insecurity and education) were also associated with quality of life.ConclusionAdvancing our understanding of patient-centered markers of quality of life, rather than focusing on pulmonary function alone, may help identify novel interventions to improve quality of life in this patient population.
