Autophagy: friend or foe in breast cancer development, progression, and treatment.
Autophagy: friend or foe in breast cancer development, progression, and treatment.
复制标题
DOI：
10.4061/2011/595092
复制
发表时间：
2011
影响因子：
1.9
通讯作者：
Todaro LB
中科院分区：
文献类型：
--
作者：
Berardi DE;Campodónico PB;Díaz Bessone MI;Urtreger AJ;Todaro LB
自噬是一种分解代谢过程，负责溶酶体降解和回收长寿命蛋白质和细胞器。这种降解途径在营养缺乏期间维持细胞存活，但在某些情况下，自噬导致细胞死亡。因此，自噬可以作为肿瘤抑制因子，因为自噬能力的降低导致恶性转化和自发性肿瘤。另一方面，这一过程也作为一种保护性细胞存活机制，对抗环境压力，导致对化疗的耐药性。 尽管自噬抑制与抗癌剂组合在某些情况下可能是治疗上有益的，但自噬诱导本身可能导致某些耐药癌症中的细胞死亡，这表明自噬诱导也可用作治疗。本文总结了有关自噬的文献中描述的最重要的发现，并讨论了这一过程在临床环境中的重要性。
Autophagy is a catabolic process responsible for the degradation and recycling of long-lived proteins and organelles by lysosomes. This degradative pathway sustains cell survival during nutrient deprivation, but in some circumstances, autophagy leads to cell death. Thereby, autophagy can serve as tumor suppressor, as the reduction in autophagic capacity causes malignant transformation and spontaneous tumors. On the other hand, this process also functions as a protective cell-survival mechanism against environmental stress causing resistance to antineoplastic therapies. Although autophagy inhibition, combined with anticancer agents, could be therapeutically beneficial in some cases, autophagy induction by itself could lead to cell death in some apoptosis-resistant cancers, indicating that autophagy induction may also be used as a therapy. This paper summarizes the most important findings described in the literature about autophagy and also discusses the importance of this process in clinical settings.