CELLULAR LOCALIZATION OF MONOAMINES IN THE SPINAL CORD.
CELLULAR LOCALIZATION OF MONOAMINES IN THE SPINAL CORD.
复制标题
单胺在脊髓中的细胞定位。
DOI：
--
复制
发表时间：
1964
期刊：
影响因子：
--
通讯作者：
Nils‐Åre Hillarp
中科院分区：
文献类型：
--
作者：
A. Carlsson;B. Falck;K. Fuxe;Nils‐Åre Hillarp
本文用荧光组织化学方法结合药理学方法和横断实验，研究了鼠和大鼠脊髓单胺的细胞定位。去甲肾上腺素（NA）和5-羟色胺（5-HT）定位于特殊的神经束系统中，这些神经束从脊髓上中心下行至外侧索和前索，终止于灰质，属于单胺能神经元。胺在神经纤维的末端部分显示出大量积聚。这有力地表明，这两种胺都是脊髓中的突触递质。前角内有许多含NA或5-HT的神经末梢。它们在后角更稀少。这两种终末都高度集中在交感神经侧柱中，在那里大多数（如果不是全部）神经细胞都被它们包围。它们至少主要起源于背外侧索的下行束。下行纤维的这种定位表明，它们与通向交感神经柱的抑制纤维相同。
The cellular localization of monoamines in the spinal cord of the mouse and the rat has been studied with the use of a fluorescence method for histochemical demonstration of certain cate-cholamines and tryptamines in combination with a pharmacological approach and transection experiments. Strong evidence was obtained for the view that noradrenaline (NA) and 5-hydroxytryptamine (5-HT) are localized in special systems of nerve tracts which from supraspinal centers descend in the lateral and anterior funiculi to terminate in the gray matter and which belong to monoaminergic neurons. The amines show a massive accumulation in the terminal part of the nerve fibres. This strongly indicates that both amines serve as synaptic transmitters in the spinal cord. Many nerve terminals containing NA or 5-HT are present in the anterior horns. They are more scarce in the posterior horns. Terminals of both kinds are highly concentrated in the sympathetic lateral column where most—if not all—of the nerve cells are surrounded by them. They originate—at least mainly—from a tract descending in the dorsolateral funiculi. This localization of the descending fibres suggests that they arc identical with the inhibitory fibres going to the sympathetic column.