parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.
parC mutations in fluoroquinolone-resistant Borrelia burgdorferi.
复制标题
氟喹诺酮耐药伯氏疏螺旋体中的 parC 突变。
DOI：
10.1128/aac.49.10.4354-4357.2005
复制
发表时间：
2005
影响因子：
4.9
通讯作者：
Samuels,DScott
中科院分区：
文献类型：
--
作者：
Galbraith,KendalM;Ng,AmandaC;Eggers,BetsyJ;Kuchel,CraigR;Eggers,ChristianH;Samuels,DScott
我们已经分离出莱姆病病原体伯氏疏螺旋体的体外氟喹诺酮耐药突变体。编码拓扑异构酶IV亚基的inparC突变与司帕沙星、阿托沙星和Bay-Y3118的敏感性丧失相关，但与环丙沙星无关。这是第一次描述的氟喹诺酮耐药的螺旋门。
We have isolated in vitro fluoroquinolone-resistant mutants of the Lyme disease agent,Borrelia burgdorferi. Mutations inparC, which encodes a subunit of topoisomerase IV, were associated with loss of susceptibility to sparfloxacin, moxifloxacin, and Bay-Y3118, but not ciprofloxacin. This is the first description of fluoroquinolone resistance in the spirochete phylum.