MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway
MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway
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MiR-126通过抑制RhoA/ROCK信号通路抑制结肠癌细胞增殖和侵袭
DOI：
10.1007/s11010-013-1664-0
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发表时间：
2013-08-01
影响因子：
4.3
通讯作者：
Wang, Xiaoyan
中科院分区：
文献类型：
--
作者：
Li, Nan;Tang, Anliu;Wang, Xiaoyan
最近的数据有力地表明了miRNA在癌症进展中的重要作用。在此，我们发现miR-126在具有高转移潜力的HCT 116、SW 620和HT-29结肠癌细胞中的表达要低得多，并且miR-126下调在具有转移的结直肠癌中更常见。恢复的miR-126表达抑制HT-29细胞生长、细胞周期进展和侵袭。微阵列结果结合生物信息学和实验分析证实miR-126通过抑制RhoA/ROCK信号通路发挥抑癌作用。这些结果表明miR-126在结肠癌进展中作为潜在的肿瘤抑制剂发挥作用，miR-126/RhoA/ROCK可能是开发合理治疗策略的新候选者。
Recent data strongly suggests the profound role of miRNAs in cancer progression. Here, we showed miR-126 expression was much lower in HCT116, SW620 and HT-29 colon cancer cells with highly metastatic potential and miR-126 downregulation was more frequent in colorectal cancers with metastasis. Restored miR-126 expression inhibited HT-29 cell growth, cell-cycle progression and invasion. Mechanically, microarray results combined with bioinformatic and experimental analysis demonstrated miR-126 exerted cancer suppressor role via inhibiting RhoA/ROCK signaling pathway. These results suggest miR-126 function as a potential tumor suppressor in colon cancer progression and miR-126/RhoA/ROCK may be a novel candidate for developing rational therapeutic strategies.