Excessive Consumption of Sugar: an Insatiable Drive for Reward
Excessive Consumption of Sugar: an Insatiable Drive for Reward
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DOI：
10.1007/s13668-019-0270-5
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发表时间：
2019-06-01
影响因子：
4.9
通讯作者：
Levine, Allen S.
中科院分区：
文献类型：
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作者：
Olszewski, Pawel K.;Wood, Erin L.;Levine, Allen S.
复习目的饮食行为提供能量以确保机体正常运作。奖励有助于寻找那些能带来能量、味道好、食用安全的食物。正如肥胖“流行病”主要源于暴饮暴食所证明的那样，当美味的食物无限量供应时，奖励就会成为一种损害。这篇综述提出了最近的证据机制的适口性驱动的糖的过度消费。对糖的胃口是由让人联想到上瘾的奖励系统的形态和活动的变化所推动的。糖的摄入也改变了饥饿-饱腹连续体，促进在没有能量需求的情况下开始进食，并维持进食，尽管摄入大量食物会危及体内平衡。摄入过量的糖依赖于促进成瘾行为的触发机制，以及凌驾于保护内部环境的神经内分泌信号。
Purpose of Review Eating behavior provides energy to ensure proper functioning of the organism. Reward aids in seeking foods that bring energy and pleasant taste, whose consumption is safe. As evidenced by the obesity "epidemic" which largely stems from overeating, reward becomes a detriment when palatable tastants are available in unlimited quantities. This review presents recent evidence on mechanisms underlying palatability-driven excessive consumption of sugar.Recent Findings Appetite for sugar is propelled by changes in the morphology and activity of the reward system reminiscent of addiction. Sugar intake also shifts the hunger-satiety continuum, facilitating initiation of consumption in the absence of energy needs and maintenance of feeding despite ingestion of large food loads that endanger homeostasis.Summary Ingestion of excessive amounts of sugar relies on triggering mechanisms that promote addictive-like behaviors, and on overriding neuroendocrine signals that protect internal milieu.