SYNTHESIS AND BIOACTIVITY OF N-(4-(N’-SUBSTITUTED SULFAMOYL) PHENYL)MYRTENAMIDES CONTAINING A HETEROCYCLE
SYNTHESIS AND BIOACTIVITY OF N-(4-(N’-SUBSTITUTED SULFAMOYL) PHENYL)MYRTENAMIDES CONTAINING A HETEROCYCLE
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杂环N-(4-(N-取代磺酰基)苯基)肉豆蔻替尼酰胺的合成及生物活性
DOI：
10.1007/s10600-018-2258-6
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发表时间：
2018
影响因子：
0.8
通讯作者：
Fuhou Lei
中科院分区：
文献类型：
--
作者：
Guishan Lin;Wengui Duan;Hongqiang Liu;Yuan Ma;Fuhou Lei
以α-蒎烯为原料，经多步反应合成了一系列含杂环的N-（4-（N′-取代氨磺酰基）苯基）桃金娘烯酰胺。初步生物活性测定结果表明，目标化合物在50 μg/mL浓度下对5种供试真菌均表现出一定的抑菌活性，其中化合物5 f对梨轮纹病菌和番茄早疫病菌的抑菌活性分别为83.2%和70.0%。化合物5d在100 μg/mL浓度下对油菜根的除草活性为86.0%。
A series ofN-(4-(N′-substituted sulfamoyl)phenyl)myrtenamides containing a heterocycle were designed and synthesized by a multiple-step procedure usingα-pinene as starting material. All the synthesized compounds were characterized and analyzed by GC, HPLC, UV-vis, FTIR, NMR, GC-MS, and ESI-MS. The preliminary bioassay showed that, at 50 μg/mL, the target compounds exhibited a certain antifungal activity against the five tested fungi, in which compound5fexhibited antifungal activity of 83.2% and 70.0% againstPhysalospora piricolaandAlternaria solani, respectively. Moreover, compound5ddisplayed herbicidal activity of 86.0% against the root of rape (Brassica campestris) at 100 μg/mL.