A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: The Frailty Interventions Trial in Elderly Subjects (FITNESS)
A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: The Frailty Interventions Trial in Elderly Subjects (FITNESS)
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DOI：
10.1046/j.1532-5415.2003.51101.x
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发表时间：
2003-03-01
影响因子：
6.3
通讯作者：
Cameron, ID
中科院分区：
文献类型：
--
作者：
Latham, NK;Anderson, CS;Cameron, ID
目的：确定维生素D和家庭式股四头肌抗阻训练对减少福尔斯和改善出院后虚弱老年人身体健康的有效性。设计：多中心、随机、对照试验，析因设计。地点：新西兰奥克兰和澳大利亚悉尼的五家医院。参与者：243名虚弱老年人。干预：患者随机接受单剂量维生素D（钙化醇，300，000 IU）或安慰剂片剂和10周的高强度家庭股四头肌阻力锻炼或频率匹配的访问。主要终点是根据3个月时的简明健康调查和6个月以上的福尔斯跌倒情况确定的身体健康。体能和自评功能是次要终点。评估发生在参与者的家中，在3个月和6个月后随机化，并进行了盲assessors.RESUTLS：有没有影响，无论是对身体健康或福尔斯的干预，但在运动组的患者在肌肉骨骼损伤的风险增加（风险比= 3.6，95%置信区间= 1.5-8.0）。补充维生素D并不能改善体能，即使是那些缺乏维生素D的人（
OBJECTIVES: To determine the effectiveness of vitamin D and home-based quadriceps resistance exercise on reducing falls and improving the physical health of frail older people after hospital discharge.DESIGN: Multicenter, randomized, controlled trial with a factorial design.SETTING: Five hospitals in Auckland, New Zealand, and Sydney, Australia.PARTICIPANTS: Two hundred forty-three frail older people.INTERVENTIONS: Patients were randomized to receive a single dose of vitamin D (calciferol, 300,000 IU) or placebo tablets and 10 weeks of high-intensity home-based quadriceps resistance exercise or frequency-matched visits.MEASUREMENTS: The primary endpoints were physical health according to the short-form health survey at 3 months and falls over 6 months. Physical performance and self-rated function were secondary endpoints. Assessments took place in the participants' homes at 3 and 6 months after randomization and were performed by blinded assessors.RESUTLS: There was no effect of either intervention on physical health or falls, but patients in the exercise group were at increased risk of musculoskeletal injury (risk ratio = 3.6, 95% confidence interval = 1.5-8.0). Vitamin D supplementation did not improve physical performance, even in those who were vitamin D deficient (