Expression of MHC class I-related molecules MICA, HLA-E and EPCR shape endothelial cells with unique functions in innate and adaptive immunity
Expression of MHC class I-related molecules MICA, HLA-E and EPCR shape endothelial cells with unique functions in innate and adaptive immunity
复制标题
DOI：
10.1016/j.humimm.2016.02.007
复制
发表时间：
2016-11-01
期刊：
影响因子：
2.7
通讯作者：
Charreau, Beatrice
中科院分区：
文献类型：
--
作者：
Gavlovsky, Pierre-Jean;Tonnerre, Pierre;Charreau, Beatrice
位于血液和组织交界处的内皮细胞(ECs)对凝血、炎症和血管稳态具有调节作用。通过表达MHC I类和II类抗原，内皮细胞也有助于免疫反应。在移植过程中，移植物内皮细胞既是同种异体免疫反应的触发者，又是其靶点。内皮细胞表达一系列与MHC I类或结构相关的分子，如人类白细胞抗原-E、MHC I类相关链A(MICA)和内皮蛋白C受体(EPCR)，为内皮细胞提供多种独特的功能。人类白细胞抗原-E是CD94/NKG2A/C受体的低多态性配体，可触发人类白细胞抗原-E限制性CD8(+)α-βT细胞对病毒和细菌肽的免疫应答。MICA是NKG2D激活NK和共刺激CD8(+)T细胞的高度多态的配体，也是组织驻留的V Delta 1伽马Delta T亚群的配体。更耐人寻味的是，作为凝血的关键调节因子，EPCR作为V Delta 2(-)Gamma Delta T细胞循环亚群的配体发挥了作用。这组MHC I类相关分子的共表达也可能影响移植的结果，这些分子允许内皮细胞在应激和感染时激活一系列微妙的免疫反应。本文就HLAE、MICA和EPCR3种基因的结构、表达、功能及其多态性的影响作一综述。(C)2016年美国组织相容性和免疫遗传学学会。爱思唯尔公司出版，版权所有。
Endothelial cells (ECs) located at the interface of blood and tissues display regulatory activities toward coagulation, inflammation and vascular homeostasis. By expressing MHC class I and II antigens, ECs also contribute to immune responses. In transplantation, graft ECs are both trigger and target of alloimmune responses. ECs express a set of MHC class I-like or structural related molecules such as HLA-E, MHC class I related chain A (MICA) and the endothelial protein C receptor (EPCR) that provide multiple and unique functions to ECs. HLA-E is a low polymorphic ligand for the CD94/NKG2A/C receptors, and triggers HLA-E-restricted CD8(+)alpha beta T cell responses against viral and bacterial peptides. MICA is a highly polymorphic ligand for NKG2D activating NK and costimulating CD8(+)T cells and a ligand for tissue-resident V delta 1 gamma delta T subsets. More intriguing is the role of EPCR, a key regulator of coagulation, as a ligand for a circulating subset of V delta 2(-) gamma delta T cells. Coexpression of this set of MHC class I-related molecules that allow ECs to activate a subtle array of immune responses upon stress and infection may also influence transplant out come. Here, the respective structure, expression, and functions of HLA-E, MICA and EPCR as well as the impact of their polymorphism are reviewed. (C) 2016 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.