Vascular effects of arginine vasotocin in toad skin.
Vascular effects of arginine vasotocin in toad skin.
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精氨酸催产素对蟾蜍皮肤的血管作用。
DOI：
10.1152/ajpregu.1993.265.2.r426
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
Malvin,GM
中科院分区：
文献类型：
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作者：
Malvin,GM
两栖动物体内的液体平衡在很大程度上受精氨酸催产素(AVT)的调节。这种激素的一个重要作用是通过增加皮肤的透水性来促进水分的吸收。皮肤血流量也影响水分吸收，但AVT对皮肤灌注量的影响尚不清楚。这项研究验证了AVT促进水分吸收的假设，不仅通过增加皮肤的透水性，而且还通过促进皮肤血液流动。通过测定皮肤对乙炔的电导(GsAc)，评估了AVT对中华大蟾蜍盆腔腹侧皮肤血流的影响。盆腔腹侧皮肤是专门吸收水分的区域。用泵灌流的皮肤制剂研究了AVT对盆腔腹侧皮肤和背部皮肤(通常不涉及水分吸收的区域)皮肤血管阻力(CVR)的影响。静脉注射10pmol/kg及以下的AVT对GsAc无明显影响(P>；0.45)。然而，100pmoL/kg和300pmoL/kg的AVT使GsAc分别下降39+/-7(P<；0.001)和63+/-6%(P<；0.001)。AVT剂量越大，平均动脉压越高。AVT增加了两种泵灌流制剂的CVR。AVT的最低浓度显著增加CVR，背部皮肤为1×10(-10)M(P=0.006)，盆腔腹侧皮肤为3×10(-10)M(P=0.038)。
Fluid balance in amphibians is regulated, in large part, by arginine vasotocin (AVT). One important action of this hormone is to facilitate water uptake by increasing the water permeability of the skin. Cutaneous blood flow also affects water uptake, but the effects of AVT on skin perfusion are unknown. This study tested the hypothesis that AVT facilitates water uptake, not only by increasing cutaneous water permeability, but also by promoting cutaneous blood flow. The effects of AVT on blood flow through the ventral pelvic skin, a region specialized for water uptake, were assessed in Bufo marinus by determining the conductance of the skin to acetylene (GsAc), an index of cutaneous blood flow. A pump-perfused skin preparation was used to study the effects of AVT on the cutaneous vascular resistance (CVR) of the ventral pelvic skin and the dorsal skin (a region not normally involved in water uptake). Bolus AVT injections (iv) of 10 pmol/kg and below had no significant effect on GsAc (P > 0.45). However, 100 and 300 pmol/kg of AVT decreased GsAc by 39 +/- 7 (P < 0.001) and 63 +/- 6% (P < 0.001), respectively. The higher AVT doses increased mean arterial pressure. AVT increased CVR in both pump-perfused preparations. The lowest concentration of AVT tested that significantly raised CVR was 1 x 10(-10) M for the dorsal skin (P = 0.006) and 3 x 10(-10) M for the ventral pelvic skin (P = 0.038).(ABSTRACT TRUNCATED AT 250 WORDS)