Genetic susceptibility to childhood leukaemia
Genetic susceptibility to childhood leukaemia
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DOI：
10.1093/rpd/ncn255
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发表时间：
2008-12-01
影响因子：
1
通讯作者：
Buffler, Patricia A.
中科院分区：
文献类型：
--
作者：
Chokkalingam, Anand P.;Buffler, Patricia A.
儿童白血病的病因被认为与成人不同，主要是由于生命早期暴露（包括子宫内暴露）的作用更明显。然而，由于研究发病率相对较低的疾病的挑战，几乎没有确定风险因素。确定的危险因素，包括电离辐射，化疗药物和特定的遗传异常，解释< 10%的发病率（（1，2））。虽然其余90%的原因尚不清楚，但可能与遗传易感性因素有关，无论是单独的还是与环境因素结合。在本文中，作者（a）审查周围的遗传易感因素的证据，重点是基因的主要影响;（B）审查北方加州儿童白血病研究（NCCLS）的一些最新进展，作为遗传流行病学研究的设计和实际考虑的案例研究;（c）强调这一令人兴奋的研究领域的挑战和未来的方向。
The aetiology of leukaemias among children is believed to be distinct from that of adults, mainly due to the clearer role for early life exposures, including those in utero. However, few risk factors have been established, because of the challenge of studying a disease with relatively low incidence. Identified risk factors, including ionizing radiation, chemotherapeutic agents and specific genetic abnormalities, explain < 10% of incidence((1,2)). Although the causes for the remaining 90% are unknown, it is possible that genetic susceptibility factors, either alone or in conjunction with environmental factors, may be involved. In this paper, the authors (a) review the evidence surrounding genetic susceptibility factors, with emphasis on the genes' main effects; (b) review some recent developments in the Northern California Childhood Leukaemia Study (NCCLS) as a case study of design and practical considerations in genetic epidemiology research and (c) highlight both challenges and future directions in this exciting research area.