In vivo behavior of three different injectable hydraulic calcium phosphate cements
In vivo behavior of three different injectable hydraulic calcium phosphate cements
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DOI：
10.1016/j.biomaterials.2003.08.073
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发表时间：
2004-03-01
期刊：
影响因子：
14
通讯作者：
von Rechenberg, B
中科院分区：
文献类型：
--
作者：
Apelt, D;Theiss, F;von Rechenberg, B
将两种二水磷酸二钙（DCPD）水硬性骨水泥和一种磷灰石水硬性骨水泥植入绵羊的骨骺和干骺端圆柱形骨缺损中。进行体内研究以评估DCPD骨水泥的生物相容性，使用磷灰石骨水泥作为对照。在2、4和6个月后，对骨水泥样本进行临床和组织学评价。通过组织形态计量学，测量了新骨形成量、纤维组织和剩余骨水泥面积随时间的变化。在所有标本中，肉眼或显微镜下均未检测到炎症体征。所有骨水泥均被不同数量的新骨替代。两种DCPD骨水泥在6个月时显示出最高的新骨形成和最少的骨水泥残留，而磷灰石在所有时间段内几乎没有变化。(C)2003 Elsevier Ltd.保留所有权利。
Two dicalcium phosphate dihydrate (DCPD) hydraulic cements and one apatite hydraulic cement were implanted in epiphyseal and metaphyseal, cylindrical bone defects of sheep. The in vivo study was performed to assess the biocompatibility of the DCPD cements, using the apatite cement as control. After time periods of 2, 4 and 6 months the cement samples were clinically and histologically evaluated. Histomorphometrically the amount of new bone formation, fibrous tissue and the area of remaining cement were measured over time. In all specimens, no signs of inflammation were detectable either macroscopically or microscopically. All cements were replaced by different amounts of new bone. The two DCPD-cements showed the highest new bone formation and least cement remnants at 6 months, whereas the apatite was almost unchanged over all time periods. (C) 2003 Elsevier Ltd. All rights reserved.