Overview of Mode of Action of Retinoids
Overview of Mode of Action of Retinoids
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类维生素A作用方式概述
DOI：
--
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
S. Barton
中科院分区：
文献类型：
--
作者：
R. Marks;A. Pearse;T. Hashimoto;S. Barton
令人惊讶的是，即使在我们生活的高度复杂和科学的时代，大部分有用的药物也来自偶然性而不是归纳推理。因此，我们经常会遇到具有治疗效果但其作用方式仍然神秘的化合物。值得记住的是，直到过去 20 或 30 年，我们才了解洋地黄和吗啡的作用原理，尽管它们已经使用了一个半世纪到两个世纪。皮质类固醇开发30多年来，经过广泛的研究，我们仍然不清楚其抗炎作用是如何发挥的。当所讨论的药物具有多种作用和治疗益处（如皮质类固醇）时，确定其使用的哪种生物学结果是主要的尤其困难。类维生素A的情况确实如此。这些药物对牛皮癣（斑块型、红皮病、脓疱型和关节病）、角化性疾病（包括鱼鳞病、变异性红斑角皮病和达里尔病）、痤疮和皮肤恶性肿瘤有效。更困难的是，它们具有多种免疫调节作用，可作为免疫佐剂，并对各种肿瘤具有预防作用。所有这些作用是否有可能可以用一种主要的生化机制来解释？
It is astonishing that even in the highly sophisticated and scientific time in which we live the bulk of useful drugs derive from serendipity rather than inductive reasoning. Because of this it is not infrequent that we are presented with compounds that are therapeutically effective but whose mode of action remains mysterious. It is worthwhile bearing in mind that it is only in the past 20 or 30 years that we have understood how digitalis and morphine work despite the fact that they were in use for between one and a half to two centuries previously. We are still not clear how the corticosteroids exert their anti-inflammatory effect even with the extensive research on the subject in the 30 odd years since their development. It is especially difficult to determine which biological result of their use is the main one when the drugs in question have multiple actions and therapeutic benefits (as with the corticosteroids). This is certainly the case with the retinoids. Here are drugs that are active in psoriasis (plaque type, erythro-dermic, pustular and arthropathic), the disorders of keratinization (including the ichthyotic disorders, erythrokeratoderma variabilis and Darier’s disease), acne and cutaneous malignancies. To make matters even more difficult they possess a variety of immunomodulating effects and act as immune adjuvants as well as having a prophylactic effect on various tumours. Is it possible that all these actions can be explained by one major biochemical mechanism?
类维生素A处理的表皮中膜糖基化的扰动。
影响因子：
13.8
作者：
Nemanic,MK;Fritsch,PO;Elias,PM
通讯作者：
Elias,PM
DOI：
10.1016/s0190-9622(82)70051-9
发表时间：
1982-01-01
影响因子：
13.8
作者：
CAMISA, C;EISENSTAT, B;WEISSMANN, G
通讯作者：
WEISSMANN, G