Fabrication of highly interconnected porous carbonate apatite blocks based on the setting reaction of calcium sulfate hemihydrate granules
Fabrication of highly interconnected porous carbonate apatite blocks based on the setting reaction of calcium sulfate hemihydrate granules
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DOI：
10.1016/j.ceramint.2021.03.324
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发表时间：
2021-06-15
影响因子：
5.2
通讯作者：
Ishikawa, Kunio
中科院分区：
文献类型：
--
作者：
Kishida, Ryo;Elsheikh, Maab;Ishikawa, Kunio
模拟松质骨的互连多孔碳酸磷灰石（CO 3Ap）块有可能作为自体移植物的替代品。本研究旨在评估通过溶解-沉淀反应将半水硫酸钙（CSH）颗粒固化反应得到的多孔二水硫酸钙（CSD）块逐步组成转化为CO 3Ap来制备块的可行性。将CSH颗粒暴露于水导致凝固反应。然而，颗粒之间的间隙被堵塞，阻止了互连多孔结构的制造。使用滤纸去除间隙中的水有利于避免间隙堵塞和制造互连的多孔CSD块。虽然CSD块转化为CaCO 3块，其通过在Na 2CO 3溶液中的溶解-沉淀反应保持互连的多孔结构，但它们的机械强度相当低（径向拉伸强度：φ = 75 kPa）。相比之下，当使用经由CSD块的热处理制成的无水硫酸钙块作为前体时，制造具有大得多的机械强度（MPa = 0.98 MPa）的CaCO 3块。当浸泡在Na 2 HPO 4溶液中时，CaCO 3块转化为CO 3Ap块（MPa = 2.1 MPa），通过溶解-沉淀反应保持互连的多孔结构。CO 3Ap块具有由颗粒之间的间隙引发的大孔和由CSH颗粒的凝固反应和溶解-沉淀反应形成CO 3Ap而产生的微孔。在本研究中得到的结果表明，这种方法是有用的，用于制造互连的多孔CO 3Ap块。
Interconnected porous carbonate apatite (CO3Ap) blocks that emulate cancellous bone have potential as an alternative to autografts. The present study aimed to evaluate the feasibility of fabricating a block via a stepwise compositional transformation to CO3Ap through dissolution-precipitation reactions of an interconnected porous calcium sulfate dihydrate (CSD) block, which was obtained by the setting reaction of calcium sulfate hemihydrate (CSH) granules. Exposure of the CSH granules to water resulted in a setting reaction. However, the gaps between the granules were clogged, preventing the fabrication of interconnected porous structures. Removing the water in the gaps using filter paper was beneficial in avoiding gap clogging and in fabricating interconnected porous CSD blocks. Although the CSD blocks transformed into CaCO3 blocks, which maintained the interconnected porous structure through a dissolution-precipitation reaction in a Na2CO3 solution, their mechanical strength was quite low (diametral tensile strength: DTS = 75 kPa). In contrast, a CaCO3 block with a much greater mechanical strength (DTS = 0.98 MPa) was fabricated when a calcium sulfate anhydrous block made via the heat treatment of the CSD block was used as a precursor. The CaCO3 block transformed into a CO3Ap block (DTS = 2.1 MPa), maintaining the interconnected porous structure through a dissolution-precipitation reaction when immersed in a Na2HPO4 solution. The CO3Ap block had macropores initiated by the gaps between the granules and micropores created by the setting reaction of CSH granules and the dissolution-precipitation reactions to form CO3Ap. The results obtained in the present study demonstrate that this method is useful for fabricating interconnected porous CO3Ap blocks.