The effects of systemic steroid therapy on macrophage migration inhibitory factor concentrations in patients with nasal polyps
The effects of systemic steroid therapy on macrophage migration inhibitory factor concentrations in patients with nasal polyps
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DOI：
10.1017/s0022215118001652
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发表时间：
2018-10-01
影响因子：
1.7
通讯作者：
Ekinci, A.
中科院分区：
文献类型：
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作者：
Ekinci, A.
目标.本研究旨在比较鼻息肉患者口服类固醇治疗前后血清巨噬细胞移动抑制因子浓度，并确定治疗前巨噬细胞移动抑制因子浓度与健康个体之间是否存在差异。这项研究包括24名鼻息肉患者和25名健康人。患者组给予1 mg/kg口服类固醇。口服类固醇治疗前患者组平均巨噬细胞移动抑制因子浓度为3889.79 pg/ml，对照组为2334.52 pg/ml。巨噬细胞移动抑制因子浓度在口服类固醇治疗前患者组中统计学显著高于对照组（p = 0.017）。口服类固醇治疗前后的平均血清巨噬细胞移动抑制因子浓度分别为3889.79 pg/ml和2451.25 pg/ml。巨噬细胞移动抑制因子浓度的降低具有统计学意义（p = 0.010）。这些结果表明，巨噬细胞移动抑制因子的浓度可能在鼻息肉的发病机制中发挥作用。
Objectives. This study aimed to compare serum macrophage migration inhibitory factor concentrations before and after oral steroid therapy in nasal polyps patients, and determine whether there is a difference between pre-treatment macrophage migration inhibitory factor concentrations and healthy individuals.Methods. The study included 24 patients with nasal polyps and 25 healthy individuals. The patient group received 1 mg/kg oral steroid.Results. The mean macrophage migration inhibitory factor concentration before oral steroid therapy was 3889.79 pg/ml in the patient group and 2334.52 pg/ml in the control group. Macrophage migration inhibitory factor concentrations were statistically significantly higher in the pre-oral steroid therapy patient group than in the control group (p = 0.017). The mean pre- and post-oral steroid therapy serum macrophage migration inhibitory factor concentrations were 3889.79 pg/ml and 2451.25 pg/ml, respectively. The reduction in macrophage migration inhibitory factor concentrations was statistically significant (p = 0.010).Conclusion. These findings suggest that concentrations of macrophage migration inhibitory factor may play a role in the pathogenesis of nasal polyps.