Validation of 133Xe Clearance as a Cerebral Blood Flow Measurement Technique during Cardiopulmonary Bypass
Validation of 133Xe Clearance as a Cerebral Blood Flow Measurement Technique during Cardiopulmonary Bypass
复制标题
133Xe Clearance 作为体外循环期间脑血流测量技术的验证
DOI：
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发表时间：
1992
影响因子：
6.3
通讯作者：
B. Leone
中科院分区：
文献类型：
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作者：
D. Spahn;T. Quill;Weicai Hu;J. Lu;L. Smith;J. Reves;R. McRae;B. Leone
用~(133)Xe清除法测定10只犬体外循环期间脑血流量(CBF)。作为参考方法，采用以133Xe为指示剂的连续Kty-Schmidt技术(CBFKS)。切除颅外组织，将133Xe探测器直接放置在颅骨上，并用3 mm的铅屏蔽头部，以减少颅外照射对133Xe清除曲线的污染。凯蒂-施密特技术的133Xe探测器被嵌入一个屏蔽的黄铜块中，以最大限度地减少对动物身体辐射的干扰。133Xe清除数据采用随机(CBF10、CBF15和CBFINF)和初始斜率方法(CBFIS)进行分析，并与CBFKS进行线性回归比较。CBF15和CBFINF的CBF值与CBFKS相似(CBFKS=0.97.CBF15−2.08，r=0.92p<；0.01；CBFKS=1.13·CBFINF−1.21，r=0.92p<；0.01)。CBF10略高估CBFKS，但仍与CBFKS密切相关(CBFKS=0.89·CBF10−2.5 8，r=0.92，p<；0.0 1)，CBFIS显著高估CBFKS(CBFKS=0.60·CBFIS−1.2 7，r=0.87，p<；0.01)。随着133Xe清除曲线的颅外污染最小化，所有用于测量CBF的133Xe清除技术都与CBFKS一致地存在显著的相关性。因此，~(133)Xe清除法是评价体外循环期间脑血流量的有效方法。
133Xe clearance to measure cerebral blood flow (CBF) was examined in 10 dogs during cardiopulmonary bypass. As a reference method, a continuous Kety–Schmidt technique (CBFKS) with 133Xe as indicator was used. Extracranial tissue was removed to directly place the 133Xe detectors on the skull, and the head was covered with a 3 mm lead shield to minimize contamination of the 133Xe clearance curve with extracranial radiation. 133Xe detectors for the Kety–Schmidt technique were embedded in a shielded brass block to minimize interference with radiation from the animal's body. 133Xe clearance data were analyzed using stochastic (CBF10, CBF15, and CBFINF) and initial slope methods (CBFIS), and the results were compared with CBFKS using linear regression. CBF15 and CBFINF yielded similar CBF values as CBFKS (CBFKS = 0.97 · CBF15 − 2.08, r = 0.92, p < 0.01; CBFKS = 1.13 · CBFINF − 1.21, r = 0.92, p < 0.01). CBF10 slightly overestimated CBFKS but still showed a close correlation to CBFKS (CBFKS = 0.89 · CBF10 − 2.58, r = 0.92, p < 0.01) and CBFIS considerably overestimated CBFKS (CBFKS = 0.60 · CBFIS − 1.27, r = 0.87, p < 0.01). With extracranial contamination of the 133Xe clearance curve minimized, all 133Xe clearance techniques used to measure CBF were consistently related to CBFKS in a constant, significant manner. 133Xe clearance therefore is a valid method to assess CBF during cardiopulmonary bypass.