Relationship between opioid therapy, tissue-damaging procedures, and brain metabolites as measured by proton MRS in asphyxiated term neonates
Relationship between opioid therapy, tissue-damaging procedures, and brain metabolites as measured by proton MRS in asphyxiated term neonates
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DOI：
10.1203/pdr.0b013e318045bde9
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发表时间：
2007-05-01
影响因子：
3.6
通讯作者：
Holshouser, Barbara A.
中科院分区：
文献类型：
--
作者：
Angeles, Danilyn M.;Ashwal, Stephen;Holshouser, Barbara A.
为了检查阿片类药物和组织损伤程序（TDP）[即在新生儿重症监护室（NICU）中进行的已知会导致疼痛、压力和组织损伤的程序]对脑代谢物的影响，我们回顾了28例窒息足月新生儿的病历（8例阿片类药物治疗，20例接受过磁共振成像（MRI）和质子磁共振波谱（MRS）的非阿片类药物治疗患者）以及8名没有窒息性损伤临床表现的新生儿。我们发现，降低肌酸（Cr）、肌醇（Ins）和N-乙酰天冬氨酸（NAA）/胆碱（Cho）（p
To examine the effects of opioid and tissue-damaging procedures (TDPs) [i.e. procedures performed in the neonatal intensive care unit (NICU) known to result in pain, stress, and tissue damage] on brain metabolites, we reviewed the medical records of 28 asphyxiated term neonates (eight opioid-treated, 20 non-opioid treated) who had undergone magnetic resonance imaging (MRI) and proton magnetic resonance spectroscopy (MRS) within the first month of life as well as eight newborns with no clinical findings of asphyxial injury. We found that lower creatine (Cr), myoinositol (Ins), and N-acetylaspartate (NAA)/choline (Cho) (p