Progression of chronic hepatitis C to liver fibrosis and cirrhosis in patients coinfected with hepatitis C virus and human immunodeficiency virus
Progression of chronic hepatitis C to liver fibrosis and cirrhosis in patients coinfected with hepatitis C virus and human immunodeficiency virus
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DOI：
10.1086/367643
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发表时间：
2003-02-15
影响因子：
11.8
通讯作者：
Girón-González, JA
中科院分区：
文献类型：
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作者：
Martinez-Sierra, C;Arizcorreta, A;Girón-González, JA
为探讨人类免疫缺陷病毒(HIV)感染患者慢性丙型肝炎演变的相关因素，对41例HIV感染的慢性丙型肝炎患者(称为HIV-丙型肝炎病毒共感染患者)和一组未感染HIV的慢性丙型肝炎患者(称为非HIV感染患者)进行了横断面分析。组织学变量与人口学参数、丙型肝炎病毒载量和基因型、HIV载量、CD4(+)T细胞计数和对高效抗逆转录病毒治疗(HAART)的反应的相关性进行了评估。与未感染HIV的患者相比，HIV-HCV合并感染的患者显示出显著更高的丙型肝炎病毒载量、更严重的纤维化和更高的肝纤维化进展率(FPR)。高的丙型肝炎病毒载量和低的CD4(+)T细胞计数与较高的FPR相关。HAART诱导的免疫反应不影响这一进展。总之，艾滋病毒-丙型肝炎病毒感染患者，主要是那些丙型肝炎病毒载量高、免疫抑制状态的患者，有更高的FPR。对HAART的免疫反应的独立影响并不明显。
To evaluate the factors associated with the evolution of chronic hepatitis C in human immunodeficiency virus (HIV)-infected patients, a cross-sectional analysis of 41 HIV-infected patients with chronic hepatitis C (known as "HIV-HCV [hepatitis C virus]-coinfected patients") and a control group of patients with chronic hepatitis C who did not have HIV infection (known as "non-HIV-infected patients") was performed. The association of histological variables with demographic parameters, HCV load and genotype, HIV load, CD4(+) T cell count, and response to highly active antiretroviral therapy (HAART) was evaluated. HIV-HCV-coinfected patients showed a significantly higher HCV load, more-advanced fibrosis, and a higher liver fibrosis progression rate (FPR) than did non-HIV-infected patients. A high HCV load and a low CD4(+) T cell count were associated with a higher FPR. The immune response induced by HAART did not influence this progression. In conclusion, HIV-HCV-infected patients, mainly such patients with a high HCV load and an immunodepressed state, have a higher FPR. An independent effect of the immune response to HAART was not evident.