Evaluation of serum cathepsin D concentrations in coronary artery disease.
Evaluation of serum cathepsin D concentrations in coronary artery disease.
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DOI：
10.1016/j.ihj.2018.01.003
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发表时间：
2018-07
影响因子：
1.5
通讯作者：
Sahebkar A
中科院分区：
文献类型：
--
作者：
Mohammadpour AH;Salehinejad Z;Elyasi S;Mouhebati M;Mirhafez SR;Samadi S;Ghayour-Mobarhan M;Ferns G;Sahebkar A
冠状动脉疾病（CAD）不能充分解释传统的危险因素的存在。组织蛋白酶D已被提出作为动脉粥样硬化的替代标志物，但其在冠心病患者中的变化尚未被研究。评价血清组织蛋白酶D浓度与冠心病存在及严重程度的关系。共招募了104名受试者；疑似冠心病71例，健康者33例。34例患者至少有一根冠状动脉狭窄（CAD+）；其余37例患者血管造影显示狭窄<50% （CAD−）。CAD+患者再分为单血管（SVD, n = 15）、双血管（2VD, n = 9）和三血管（3VD, n = 10）三个亚组。采用酶联免疫吸附试验（ELISA）测定血清可溶性组织蛋白酶D浓度。CAD+组血清组织蛋白酶D浓度显著高于健康对照组（p = 0.016），而CAD -组无显著差异（p = 0.098）。在CAD+组中，3VD患者的血清组织蛋白酶D浓度明显高于SVD组（p = 0.025），也高于CAD -组（p = 0.011）和SVD组（p = 0.001）。血清组织蛋白酶D浓度与潜在混杂因素（包括年龄、性别、血压、吸烟史和血脂异常）之间未发现显著关联。血清组织蛋白酶D浓度可能与冠心病的存在有关。
Coronary artery disease (CAD) cannot be sufficiently explained by the presence of traditional risk factors. Cathepsin D has been proposed to serve as a surrogate marker of atherosclerosis but its alterations in CAD patients have not been studied. To evaluate serum cathepsin D concentrations in relation to the presence and severity of CAD. A total of 104 subjects were recruited; 71 patients with suspected CAD and 33 healthy subjects. Thirty-four patients had >50% coronary stenosis of at least one artery (CAD+); the remaining 37 patients had <50% stenosis (CAD−) based on angiography. CAD+ patients were sub-divided into three sub-groups with single (SVD; n = 15), double (2VD; n = 9), and triple vessel (3VD; n = 10) disease. Serum soluble cathepsin D concentrations were determined using an enzyme-linked immunosorbent assay (ELISA). Serum cathepsin D concentrations were significantly higher in the CAD+ compared with healthy control (p = 0.016) but not CAD− group (p = 0.098). Within the CAD+ group, patients with 3VD had significantly higher serum cathepsin D concentrations compared with the SVD group (p = 0.025), and also compared with the CAD− (p = 0.011) and SVD (p = 0.001) groups. No significant associations were found between serum cathepsin D concentrations and potential confounders including age, sex, blood pressure, smoking history and dyslipidemia. Serum cathepsin D concentrations may be associated with the presence of CAD.