High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)
High prevalence of antimicrobial resistance among clinical Streptococcus pneumoniae isolates in Asia (an ANSORP study)
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DOI：
10.1128/aac.48.6.2101-2107.2004
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发表时间：
2004-06-01
影响因子：
4.9
通讯作者：
Shibl, A
中科院分区：
文献类型：
--
作者：
Song, JH;Jung, SI;Shibl, A
2000年1月至2001年6月，从11个亚洲国家的14个中心共收集了685株来自肺炎球菌疾病患者的肺炎链球菌临床分离株。采用微量肉汤稀释法测定了分离菌株对14种抗菌药物的体外敏感性。在检测的分离株中，483株（52.4%）对青霉素不敏感，23%为中间型，29.4%为青霉素耐药（MIC大于或等于2 mg/L）。来自越南的分离株显示出最高的青霉素耐药性流行率（71.4%），其次是来自韩国（54.8%）、香港（43.2%）和台湾（38.6%）。在来自越南、香港、韩国和台湾的分离株中，90%分离株被抑制的青霉素MIC（MIC（90）s）为4 mg/L。在越南（92.1%）、中国台湾（86%）、韩国（80.6%）、中国香港（76.8%）和中国大陆（73.9%），红霉素耐药的患病率也非常高。在韩国、越南、中国、台湾、新加坡、马来西亚和香港的分离株中，红霉素的MIC（90）>32 mg/L。来自香港的分离株显示出最高的环丙沙星耐药率（11.8%），其次是来自斯里兰卡（9.5%）、菲律宾（9.1%）和韩国（6.5%）的分离株。多位点序列分型表明，台湾（19 F）克隆和西班牙（23 F）克隆的传播可能是沙门氏菌耐药性迅速增加的主要原因之一。肺炎分离株。来自多国监测研究的数据清楚地记录了沙门氏菌的流行率和抗菌素耐药性水平的明显增加。肺炎分离株在许多亚洲国家，这是世界上最高的出版日期。
A total of 685 clinical Streptococcus pneumoniae isolates from patients with pneumococcal diseases were collected from 14 centers in 11 Asian countries from January 2000 to June 2001. The in vitro susceptibilities of the isolates to 14 antimicrobial agents were determined by the broth microdilution test. Among the isolates tested, 483 (52.4%) were not susceptible to penicillin, 23% were intermediate, and 29.4% were penicillin resistant (MICs greater than or equal to 2 mg/liter). Isolates from Vietnam showed the highest prevalence of penicillin resistance (71.4%), followed by those from Korea (54.8%), Hong Kong (43.2%), and Taiwan (38.6%). The penicillin MICs at which 90% of isolates are inhibited (MIC(90)s) were 4 mg/liter among isolates from Vietnam, Hong Kong, Korea, and Taiwan. The prevalence of erythromycin resistance was also very high in Vietnam (92.1%), Taiwan (86%), Korea (80.6%), Hong Kong (76.8%), and China (73.9%). The MIC(90)s of erythromycin were >32 mg/liter among isolates from Korea, Vietnam, China, Taiwan, Singapore, Malaysia, and Hong Kong. Isolates from Hong Kong showed the highest rate of ciprofloxacin resistance (11.8%), followed by isolates from Sri Lanka (9.5%), the Philippines (9.1%), and Korea (6.5%). Multilocus sequence typing showed that the spread of the Taiwan(19F) clone and the Spain(23F) clone could be one of the major reasons for the rapid increases in antimicrobial resistance among S. pneumoniae isolates in Asia. Data from the multinational surveillance study clearly documented distinctive increases in the prevalence rates and the levels of antimicrobial resistance among S. pneumoniae isolates in many Asian countries, which are among the highest in the world published to date.