The dirty aspects of fecal microbiota transplantation: a review of its adverse effects and complications
The dirty aspects of fecal microbiota transplantation: a review of its adverse effects and complications
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DOI：
10.1016/j.coph.2019.04.008
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发表时间：
2019-12-01
影响因子：
4
通讯作者：
Tahan, Veysel
中科院分区：
文献类型：
--
作者：
Dailey, Francis E.;Turse, Erica P.;Tahan, Veysel
粪便微生物群移植正在成为多种适应症的日益增长的治疗方法，包括复发性或难治性艰难梭菌感染（CDI）以及许多其他胃肠道和肠外疾病。事实上，粪便微生物群移植现在被强烈推荐为CDI多发性复发的治疗选择，因为它具有强大的疗效和良好的短期副作用。随着这种疗法的应用范围扩大，对其不良事件的认识也有所提高。本综述的目的是揭示与粪便微生物群移植相关的副作用和并发症，重点是最近发表的研究结果。
Fecal microbiota transplantation is becoming a growing therapy for a variety of indications, including recurrent or refractory Clostridium difficile infection (CDI), as well as many other gastrointestinal and extra-intestinal diseases. In fact, fecal microbiota transplantation is now strongly recommended as the treatment of choice for multiple recurrences of CDI, given its strong efficacy and a favorable short-term side effect profile. As the application of this therapy expands, awareness of its adverse events has also developed. The purpose of this review is to bring to light the side effects and complications associated with fecal microbiota transplantation, with an emphasis on findings from recently published studies.