Allergic and nonallergic rhinitis: the threat for obstructive sleep apnea
Allergic and nonallergic rhinitis: the threat for obstructive sleep apnea
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DOI：
10.1016/s1081-1206(10)60138-x
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发表时间：
2009-07-01
影响因子：
5.9
通讯作者：
Ekici, Mehmet
中科院分区：
文献类型：
--
作者：
Kalpaklioglu, A. Fuesun;Kavut, Ayse Baccioglu;Ekici, Mehmet
背景：虽然变应性鼻炎(AR)被认为是阻塞性睡眠呼吸暂停综合征(OSAS)的危险因素，但非变应性鼻炎(NAR)的作用尚不清楚。目的：比较AR和NAR患者的OSAS。方法：对48例AR和NAR成人进行了一项观察性研究，包括鼻炎和睡眠症状的回顾、皮肤点刺试验结果、自填问卷(Epworth嗜睡量表和36项简明健康调查)结果和整夜多导睡眠图记录。结果：最常见的睡眠症状是打鼾症。AR患者的睡眠时间和睡眠效率明显高于NAR患者。这两组人都有频繁的性唤醒。36%的AR患者和83%的NAR患者被诊断为OSAS(P=.001)。重度OSAS仅见于NAR组。NAR与OSAS(优势比，6.4)和呼吸暂停(优势比，0.2)有很高的相关性。体重指数、性别和合并哮喘对OSAS没有任何可预测的影响，但年龄与OSAS相关。两组患者的生活质量损害程度相似。结论：AR和NAR均为高呼吸暂停低通气指数的危险因素，且两者均易发生睡眠呼吸暂停。然而，根据多导睡眠图受损的结果和更高的Epworth嗜睡量表评分，NAR似乎有更大的风险。因此，鼻炎患者不仅应该针对鼻部症状进行治疗，还应该针对更好的睡眠质量进行治疗。过敏性哮喘免疫。2009年；103：20-25。
Background: Although allergic rhinitis (AR) is accepted as a risk factor for obstructive sleep apnea syndrome (OSAS), the role of nonallergic rhinitis (NAR) is unknown.Objective: To compare OSAS in patients with AR vs NAR.Methods: We performed an observational study in 48 adults with AR and NAR that included a review of rhinitis and sleep symptoms, skin prick test results, self-administered questionnaire (Epworth Sleepiness Scale and 36-Item Short Form Health Survey) findings, and all-night polysomnography records.Results: The most frequent sleep symptom was snoring. Patients with AR had a significantly longer sleep duration and better sleep efficiency than did those with NAR. Both groups had frequent arousals. OSAS was diagnosed in 36% of patients with AR and in 83% of those with NAR (P = .001). Severe OSAS existed only in the NAR group. NAR showed a high correlation with OSAS (odds ratio, 6.4) and with apneas (odds ratio, 0.2). Body mass index, sex, and coexisting asthma did not have any predictable effect on OSAS, but age was correlated with OSAS. The impairment in quality of life was similar in both groups.Conclusions: Both AR and NAR are risk factors for a high apnea-hypopnea index, and both can predispose to sleep apnea. However, NAR seems to have a greater risk according to impaired polysomnography results and higher Epworth Sleepiness Scale scores. Therefore, patients with rhinitis should be treated not only for nasal symptoms but also for a better quality of sleep. Ann Allergy Asthma Immunol. 2009; 103:20-25.