Methods for Quantifying Three-Dimensional Deformation of Arteries due to Pulsatile and Nonpulsatile Forces: Implications for the Design of Stents and Stent Grafts
Methods for Quantifying Three-Dimensional Deformation of Arteries due to Pulsatile and Nonpulsatile Forces: Implications for the Design of Stents and Stent Grafts
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DOI：
10.1007/s10439-008-9590-0
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发表时间：
2009-01-01
影响因子：
3.8
通讯作者：
Taylor, Charles A.
中科院分区：
文献类型：
--
作者：
Choi, Gilwoo;Cheng, Christopher P.;Taylor, Charles A.
了解血管系统的动态变化对于确保血管内器械的安全性和有效性变得越来越重要。我们开发了新的方法来量化在体内三维（3D）动脉变形由于脉动和非脉动力。一个二维阈值分割技术结合水平集方法，使计算的横截面血管腔的一致的质心，而最佳的傅立叶平滑技术的开发，以消除虚假的不规则的中心线连接的质心。利用纵向应变和轴向扭曲和曲率变化的新指标来表征由于肌肉骨骼运动引起的腹主动脉、髂总动脉和股浅动脉（SFA）的3D变形以及由于心脏脉动运动引起的冠状动脉变形。这些说明性应用示出了每个变形度量的意义，揭示了SFA和冠状动脉中的显著纵向应变和轴向扭曲，以及冠状动脉和SFA的下部区域中的血管曲率的显著变化。所提出的方法可以帮助设计临床前试验，旨在复制动脉树中的动态体内条件，以开发更耐用的血管内器械，包括支架和支架移植物。
The knowledge of dynamic changes in the vascular system has become increasingly important in ensuring the safety and efficacy of endovascular devices. We developed new methods for quantifying in vivo three-dimensional (3D) arterial deformation due to pulsatile and nonpulsatile forces. A two-dimensional threshold segmentation technique combined with a level set method enabled calculation of the consistent centroid of the cross-sectional vessel lumen, whereas an optimal Fourier smoothing technique was developed to eliminate spurious irregularities of the centerline connecting the centroids. Longitudinal strain and novel metrics for axial twist and curvature change were utilized to characterize 3D deformations of the abdominal aorta, common iliac artery, and superficial femoral artery (SFA) due to musculoskeletal motion and deformations of the coronary artery due to cardiac pulsatile motion. These illustrative applications show the significance of each deformation metric, revealing significant longitudinal strain and axial twist in the SFA and coronary artery, and pronounced changes in vessel curvature in the coronary artery and in the inferior region of the SFA. The proposed methods may aid in designing preclinical tests aimed at replicating dynamic in vivo conditions in the arterial tree for the purpose of developing more durable endovascular devices including stents and stent grafts.