Influence of theophylline on fetal rat lung phosphatidylcholine synthesis in vivo.
Influence of theophylline on fetal rat lung phosphatidylcholine synthesis in vivo.
复制标题
茶碱对胎鼠肺磷脂酰胆碱体内合成的影响。
DOI：
10.1159/000457017
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Gross,I
中科院分区：
文献类型：
--
作者：
Moya,FR;Gross,I
为了解决关于茶碱在体内刺激胎鼠肺表面活性物质产生的有效性的相互矛盾的报道，我们研究了茶碱对胎鼠肺磷脂酰胆碱合成的影响。给怀孕大鼠腹腔注射茶碱后，母鼠和胎鼠的血清水平均升高。胎儿与母亲的比例为0.85：0.90。剂量为5~180 mg/kg/d的茶碱不会增加胆碱掺入磷脂酰胆碱或其饱和物种的速率。这些磷脂在肺组织中的浓度也没有增加。在无毒血清水平下，茶碱似乎不能刺激胎鼠肺磷脂酰胆碱的合成。
In an attempt to resolve conflicting reports on the effectiveness of theophylline in stimulating fetal lung surfactant production in vivo, we examined the influence of theophylline on fetal rat lung phosphatidylcholine synthesis. Intraperitoneal administration of theophylline to the pregnant rat produced elevated serum levels in both mother and fetus. The fetal:maternal ratio was 0.85:0.90. Doses of theophylline ranging between 5 and 180 mg/kg/day resulted in no increase in the rate of incorporation of choline into phosphatidylcholine or its disaturated species. There was also no increase in the lung tissue concentration of these phospholipids. Theophylline does not appear to stimulate fetal rat lung phosphatidylcholine synthesis at nontoxic serum levels.