The international Perinatal Outcomes in the Pandemic (iPOP) study: protocol.
The international Perinatal Outcomes in the Pandemic (iPOP) study: protocol.
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DOI：
10.12688/wellcomeopenres.16507.1
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发表时间：
2021
影响因子：
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通讯作者：
iPOP Study Team
中科院分区：
文献类型：
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作者：
Stock SJ;Zoega H;Brockway M;Mulholland RH;Miller JE;Been JV;Wood R;Abok II;Alshaikh B;Ayede AI;Bacchini F;Bhutta ZA;Brew BK;Brook J;Calvert C;Campbell-Yeo M;Chan D;Chirombo J;Connor KL;Daly M;Einarsdóttir K;Fantasia I;Franklin M;Fraser A;Håberg SE;Hui L;Huicho L;Magnus MC;Morris AD;Nagy-Bonnard L;Nassar N;Nyadanu SD;Iyabode Olabisi D;Palmer KR;Pedersen LH;Pereira G;Racine-Poon A;Ranger M;Rihs T;Saner C;Sheikh A;Swift EM;Tooke L;Urquia ML;Whitehead C;Yilgwan C;Rodriguez N;Burgner D;Azad MB;iPOP Study Team
早产是全球婴儿死亡的主要原因，但早产的原因在很大程度上是未知的。在COVID-19封锁初期，据报道早产大幅减少;然而，这些趋势可能被死产率的增加所抵消。随着大流行的持续，研究全球这些趋势并了解根本原因非常重要。封锁极大地影响了产妇的工作量，获得医疗保健，卫生习惯和空气污染-所有这些都可能影响围产期结果，并可能对世界不同地区的孕妇产生不同的影响。 在国际大流行围产期结局（iPOP）研究中，我们将抓住COVID-19大流行提供的独特机会，回答有关围产期健康的紧迫问题。在前两个研究阶段，我们将使用基于人群的汇总数据和标准化结局定义：1）确定早产、低出生体重和死胎的发生率，并描述封锁期间的变化;并评估这些变化是否在全球范围内保持一致，或因地区和收入环境而异，2）确定封锁期间不良围产期结局的变化幅度是否因COVID-19感染率的地区差异、封锁的严格程度、遵守封锁措施，空气质量或其他社会和经济指标，从公开数据集获得。我们将对2015年1月至2020年7月的出生人口进行中断的时间序列分析。 iPOP研究将涉及来自37个国家的至少121名研究人员，包括产科医生、妇科医生、流行病学家、公共卫生研究人员、环境科学家和政策制定者。我们将利用我们一生中最具破坏性和最广泛的“自然实验”来快速发现早产。无论COVID-19大流行是恶化还是意外改善围产期结局，我们的研究都将提供关键的新信息，以制定整个（以及超越）大流行的产前护理策略。
Preterm birth is the leading cause of infant death worldwide, but the causes of preterm birth are largely unknown. During the early COVID-19 lockdowns, dramatic reductions in preterm birth were reported; however, these trends may be offset by increases in stillbirth rates. It is important to study these trends globally as the pandemic continues, and to understand the underlying cause(s). Lockdowns have dramatically impacted maternal workload, access to healthcare, hygiene practices, and air pollution - all of which could impact perinatal outcomes and might affect pregnant women differently in different regions of the world. In the international Perinatal Outcomes in the Pandemic (iPOP) Study, we will seize the unique opportunity offered by the COVID-19 pandemic to answer urgent questions about perinatal health. In the first two study phases, we will use population-based aggregate data and standardized outcome definitions to: 1) Determine rates of preterm birth, low birth weight, and stillbirth and describe changes during lockdowns; and assess if these changes are consistent globally, or differ by region and income setting, 2) Determine if the magnitude of changes in adverse perinatal outcomes during lockdown are modified by regional differences in COVID-19 infection rates, lockdown stringency, adherence to lockdown measures, air quality, or other social and economic markers, obtained from publicly available datasets. We will undertake an interrupted time series analysis covering births from January 2015 through July 2020. The iPOP Study will involve at least 121 researchers in 37 countries, including obstetricians, neonatologists, epidemiologists, public health researchers, environmental scientists, and policymakers. We will leverage the most disruptive and widespread “natural experiment” of our lifetime to make rapid discoveries about preterm birth. Whether the COVID-19 pandemic is worsening or unexpectedly improving perinatal outcomes, our research will provide critical new information to shape prenatal care strategies throughout (and well beyond) the pandemic.