Central effects of neuromedin U in the regulation of energy homeostasis
Central effects of neuromedin U in the regulation of energy homeostasis
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DOI：
10.1006/bbrc.2000.3669
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发表时间：
2000-10-14
影响因子：
3.1
通讯作者：
Matsukura, S
中科院分区：
文献类型：
--
作者：
Nakazato, M;Hanada, R;Matsukura, S
神经素U （Neuromedin U， NMU）是一种脑肠肽，其外周活性已被充分了解，但其中枢作用尚未明确。最近在大鼠脑中发现了两种NMU受体，为进一步研究其在中枢神经系统中的作用提供了一个跳板。自由饲养大鼠脑室内给予NMU可减少食物摄取量和体重。相反，NMU增加了总运动活动、体温和产热。NMU是一种有效的内源性厌食肽，在大脑中作为分解代谢信号分子。进一步研究NMU的生化和生理功能有助于我们更好地理解能量稳态的机制。(C) 2000年学术出版社。
Neuromedin U (NMU) is a brain-gut peptide whose peripheral activities are well-understood but whose central actions have yet to be clarified. The recent identification of two NMU receptors in rat brain has provided a springboard for further investigation into its role in the central nervous system. Intracerebroventricular administration of NMU to free-feeding rats decreased food intake and body weight. Conversely, NMU increased gross locomotor activity, body temperature, and heat production. NMU, a potent endogenous anorectic peptide, serves as a catabolic signaling molecule in the brain. Further investigation of the biochemical and physiological functions of NMU will help our better understanding of the mechanisms Of energy homeostasis. (C) 2000 Academic Press.