Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells
Static and dynamic light scattering of healthy and malaria-parasite invaded red blood cells
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DOI：
10.1117/1.3369966
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发表时间：
2010-03-01
影响因子：
3.5
通讯作者：
Feld, Michael S.
中科院分区：
文献类型：
--
作者：
Park, YongKeun;Diez-Silva, Monica;Feld, Michael S.
我们提出了个人的恶性疟原虫寄生的人红细胞（Pf-RBC）的光散射，并展示了渐进的变化所产生的发展疟疾诱导寄生虫的散射信号。通过使用定量相位显微镜和傅立叶变换光散射技术选择性地成像电场，我们计算单个Pf-RBC的光散射图。我们表明，可以清楚地确定的静态散射图的发病和发展的病理状态的Pf-RBC。从动态光散射捕获Pf-RBC膜的生物物理性质的渐进变化。(C)2010年，美国光电仪器工程师学会。[DOI：10.1117/1.3369966]
We present the light scattering of individual Plasmodium falciparum-parasitized human red blood cells (Pf-RBCs), and demonstrate progressive alterations to the scattering signal arising from the development of malaria-inducing parasites. By selectively imaging the electric fields using quantitative phase microscopy and a Fourier transform light scattering technique, we calculate the light scattering maps of individual Pf-RBCs. We show that the onset and progression of pathological states of the Pf-RBCs can be clearly identified by the static scattering maps. Progressive changes to the biophysical properties of the Pf-RBC membrane are captured from dynamic light scattering. (C) 2010 society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3369966]