Antidonor antibody in patients receiving ABO-identical and HLA-mismatched living donor liver transplants: Effect on survival
Antidonor antibody in patients receiving ABO-identical and HLA-mismatched living donor liver transplants: Effect on survival
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DOI：
10.1097/01.tp.0000251361.12249.a1
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发表时间：
2007-02-27
期刊：
影响因子：
6.2
通讯作者：
Maekawa, Taira
中科院分区：
文献类型：
--
作者：
Ashihara, Eishi;Tsuji, Hiroaki;Maekawa, Taira
我们回顾性地确定了通过直接补体依赖性细胞毒性进行的淋巴细胞交叉配型试验结果与585例连续ABO相合和人类白细胞抗原（HLA）不相合的活体肝移植（LDLT）结局的相关性（男性：女性=276：309;中位年龄18岁）。交叉配血试验阳性14例（2.4%）。交叉配型阳性组患者8年生存率显著低于交叉配型阴性组（阳性组，56.3%;阴性组，77.6%; P=0.014）。交叉配型阳性组的5年生存率显著低于阴性组，包括年龄≥ 18岁的受者（阳性组41.7%;阴性组76.4%; P=0.0065）和女性受者（阳性组37.5%;阴性组81.9%; P=3.3 × 10 - 5）。我们得出结论，抗供体抗体对LDLT的临床结果有不良影响，女性和/或年龄较大（≥ 18岁）是LDLT的危险因素。
We retrospectively determined the correlation of results of lymphocyte crossmatch tests by direct complement-dependent cytotoxicity, to the outcomes of 585 consecutive ABO-identical and human leukocyte antigen (HLA)-mismatched living donor liver transplants (LDLTs) (male:female=276:309; median age, 18 years). Crossmatch test results were positive in 14 recipients (2.4%). Patient survival at eight years in the crossmatch-positive group was significantly lower than in the crossmatch-negative group (positive group, 56.3%; negative group, 77.6%; P=0.014). The survival at five years of the crossmatch-positive group was significantly lower than the negative group in both older recipients (>= 18 years of age: positive group, 41.7%; negative group, 76.4%; P=0.0065), and female recipients (positive group, 37.5%; negative group, 81.9%; P=3.3 x 10(-5)). We conclude that antidonor antibodies have adverse effects on the clinical outcome of LDLTs, and that being female and/or older aged (>= 18 years of age) are risk factors for LDLT.