Incidence of Crohn’s disease in Stockholm County 1955–1989
Incidence of Crohn’s disease in Stockholm County 1955–1989
复制标题
1955 年至 1989 年斯德哥尔摩县克罗恩病的发病率
作者：
A. Lapidus;O. Bernell;G. Hellers;P. Persson;R. Löfberg
目的评价1955年至1989年斯德哥尔摩县克罗恩病的发病率。方法：回顾性收集了1936例克罗恩病患者的队列研究。对发病率和疾病分布的变化进行了评估。结果：在过去的20年中，发病率每5年平均增加15%（95%置信区间为12%~ 18%），平均年发病率为4.6/10万。男性和女性在整个研究期间的平均发生率相似。诊断时的平均年龄从1960-64年的25岁增加到1985-89年的32岁，部分原因是诊断时年龄至少60岁的患者比例增加。在研究期间，诊断时结肠克罗恩病患者的比例从15%增加到32%（17%差异; 95%置信区间12%至23%），而回盲部疾病患者的比例从58%下降到41%（17%差异; 95%置信区间10%至24%）。与年轻患者相比，老年患者小肠疾病的比例较高，回结肠疾病的比例较低。结论：斯德哥尔摩克罗恩病的发病率稳定在4.6/10万，老年患者的比例在35年内有所增加。结肠克罗恩病的发病率增加，回盲部疾病的发病率相应降低。
Aim—To evaluate the incidence of Crohn’s disease in Stockholm County between 1955 and 1989. Methods—A cohort of 1936 patients with Crohn’s disease was retrospectively assembled. Incidence rates and changes in disease distribution were assessed. Results—The mean increase in incidence was 15% (95% confidence intervals 12% to 18%) per five year period with a mean annual incidence rate at 4.6/105during the last two decades. The mean incidence for the entire study period was similar for men and women. The mean age at diagnosis increased from 25 years in 1960–64 to 32 years in 1985–89, partly because of an increasing proportion of patients aged at least 60 years at diagnosis. The proportion of patients with colonic Crohn’s disease at the time of diagnosis increased from 15% to 32% (17% difference; 95% confidence intervals 12% to 23%) whereas the proportion of patients with ileocaecal disease decreased from 58% to 41% (17% difference; 95% confidence intervals 10% to 24%) during the study period. Elderly patients had a higher proportion of small bowel disease and a lower proportion of ileocolonic disease compared with the younger patients. Conclusion—The incidence rate of Crohn’s disease in Stockholm has stabilised at 4.6/105 and the proportion of elderly patients has increased during a 35 year period. Colonic Crohn’s disease has increased in frequency with a reciprocal decrease in ileocaecal disease.