N-acetylaspartate levels in bipolar offspring with and at high-risk for bipolar disorder
N-acetylaspartate levels in bipolar offspring with and at high-risk for bipolar disorder
复制标题
DOI：
10.1111/j.1399-5618.2005.00266.x
复制
发表时间：
2005-12-01
影响因子：
5.4
通讯作者：
Chang, KD
中科院分区：
文献类型：
--
作者：
Gallelli, KA;Wagner, CM;Chang, KD
目的：有研究报道，双相情感障碍（BD）成人和儿童的背外侧前额叶皮层（DLPFC）中的N-乙酰天冬氨酸（NAA）减少，表明该区域的神经元密度降低。然而，目前尚不清楚这一发现是否代表BD发病后的神经退行性变或BD发病前存在的性状标记。为了解决这个问题，我们使用质子磁共振波谱（H-1-MRS）比较了患有早发性BD的双相子女、患有BD亚综合征症状的双相子女和健康儿童的NAA DLPFC水平。方法：参与者年龄在9-18岁之间，包括60名父母患有双相I型或II型障碍的后代（32例BD和28例BD亚综合征症状）和26例健康对照。结果：两组间左、右侧DLPFC的NAA/Cr比值无显著性差异。其他代谢物（肌醇、胆碱）的探索性分析也未产生显著的组间差异。NAA/Cr比值与年龄，病程，或暴露于锂或丙戊酸盐。结论：我们的研究结果表明，DLPFC NAA/Cr比值不能被用作BD的性状标记。尽管我们没有发现BD儿童和青少年的DLPFC NAA/Cr比值降低，但在疾病持续时间延长至成年后，这种水平开始降低仍是可能的。需要对BD患者的发育和治疗因素进行纵向神经影像学研究，以进一步阐明BD的神经变性方面。
Objectives: Studies have reported decreased N-acetylaspartate (NAA) in dorsolateral prefrontal cortex (DLPFC) of adults and children with bipolar disorder (BD), suggesting decreased neuronal density in this area. However, it is unclear if this finding represents neurodegeneration after or a trait marker present before BD onset. To address this question, we used proton magnetic resonance spectroscopy (H-1-MRS) to compare DLPFC levels of NAA among bipolar offspring with early-onset BD, bipolar offspring with subsyndromal symptoms of BD and healthy children.Methods: Participants were 9-18 years old, and included 60 offspring of parents with bipolar I or II disorder (32 with BD and 28 with subsyndromal symptoms of BD), and 26 healthy controls. H-1-MRS at 3 T was used to study 8-cm(3) voxels placed in left and right DLPFC.Results: There were no significant group differences in mean right or left DLPFC NAA/Cr ratios. Exploratory analyses of additional metabolites (myoinositol, choline) also yielded no significant group differences. NAA/Cr ratios were not correlated with age, duration of illness, or exposure to lithium or valproate.Conclusions: Our findings suggest that DLPFC NAA/Cr ratios cannot be used as a trait marker for BD. Although we did not find decreased DLPFC NAA/Cr ratios in children and adolescents with BD, it is still possible that such levels begin to decrease after longer durations of illness into adulthood. Longitudinal neuroimaging studies of patients with BD accounting for developmental and treatment factors are needed to further clarify the neurodegenerative aspects of BD.