Self-reported Instances of Major Discrimination, Race/Ethnicity, and Inflammation Among Older Adults: Evidence From the Health and Retirement Study
Self-reported Instances of Major Discrimination, Race/Ethnicity, and Inflammation Among Older Adults: Evidence From the Health and Retirement Study
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DOI：
10.1093/gerona/gly267
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发表时间：
2020-02-01
影响因子：
5.1
通讯作者：
Thorpe, Roland J., Jr.
中科院分区：
文献类型：
--
作者：
Cobb, Ryon J.;Parker, Lauren J.;Thorpe, Roland J., Jr.
背景资料：本研究探讨了老年人自我报告的主要歧视和炎症之间的关系，并探讨了这种关系是否因种族/民族而异。我们假设自我报告的严重歧视事件与高风险炎症水平相关，并且这种关系在种族/民族少数群体中比白人更强。方法：来自2006/2008年健康与退休研究的数据，这是一项正在进行的两年一度的美国老年人全国代表性样本，被用来收集措施的自我报告的情况下，主要歧视和高风险的C-反应蛋白（CRP），这是从血液样本分析。改良泊松回归与稳健的标准误差被应用于估计自我报告的主要歧视情况的患病率，因为它与高危CRP有关。结果：经历过任何重大歧视事件的受访者有较高的可能性患高风险CRP（患病率[PR]：1.14，95%置信区间[CI] = 1.07-1.22）比那些没有报告经历任何重大歧视的人。这种关联独立于新诊断的健康状况和社会经济地位的差异。任何自我报告的重大歧视和高风险CRP的情况下，黑人比白人（PR：0.81，95%CI = 0.69-0.95）之间的关系弱：结论：我们的研究证实，自我报告的重大终身歧视的情况下，是一个心理社会因素，是不利的老年人中的高风险CRP，这种关联是特别明显的老年白人。需要在这一人群中进行进一步研究，以检查自我报告的重大歧视事件与高风险CRP之间的关系是否会随着时间的推移而变化。
Background: This study examines the relationship between self-reported instances of major discrimination and inflammation among older adults, and explores whether this relationship varies in accordance with race/ethnicity. We hypothesized that self-reported instances of major discrimination would be associated with higher levels of high-risk inflammation and that this relationship would be stronger for racial/ethnic minorities than whites.Methods: Data from the 2006/2008 Health and Retirement Study, an ongoing biennial nationally representative sample of older adults in the United States, were used to collect measures of self-reported instances of major discrimination and high-risk C-reactive protein (CRP), which was assayed from blood samples. Modified Poisson regression with robust standard errors was applied to estimate the prevalence ratios of self-reported instances of major discrimination, as it relates to high-risk CRP (CRP >= 22 kg/m(2)), and test whether this relationship varies by race/ethnicity.Results: Respondents who experienced any instances of major discrimination had a higher likelihood of high-risk CRP (prevalence ratio [PR]: 1.14, 95% confidence interval [CI] = 1.07-1.22) than those who did not report experiencing any instances of major discrimination. This association was independent of differences in newly diagnosed health conditions and socioeconomic status. The relationship between any self-reported instance of major discrimination and high-risk CRP was weaker for blacks than whites (PR: 0.81, 95% CI = 0.69-0.95).Conclusions: Our study confirms that self-reported instances of major lifetime discrimination is a psychosocial factor that is adversely associated with high-risk CRP among older adults; this association is especially pronounced among older whites. Future studies among this population are required to examine whether the relationship between self-reported instances of major discrimination and high-risk CRP changes over time.