THE PH OSCILLATIONS IN ARTERIAL BLOOD DURING EXERCISE - A POTENTIAL SIGNAL FOR THE VENTILATORY RESPONSE IN THE DOG
THE PH OSCILLATIONS IN ARTERIAL BLOOD DURING EXERCISE - A POTENTIAL SIGNAL FOR THE VENTILATORY RESPONSE IN THE DOG
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DOI：
10.1113/jphysiol.1982.sp014290
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发表时间：
1982-01-01
影响因子：
5.5
通讯作者：
STIDWILL, R
中科院分区：
文献类型：
--
作者：
CROSS, BA;DAVEY, A;STIDWILL, R
在T胸8/9（皮节水平T6/7）脊髓横断的氯醛糖麻醉狗中研究了电诱导运动对动脉pH呼吸振荡的影响。动脉 pH 值的呼吸振荡（推测是由于动脉 PCO2[CO2 分压]的振荡所致）通过 1 条颈动脉中的快速响应电极进行感测。通过对 pH 信号进行微分，获得了 pH 振荡下冲程 pH 最大变化率 (dpH/dt.dwnarw.max) 的逐次呼吸估计。运动对通气的反应不能用对二氧化碳的敏感性来解释；运动时的.DELTA..ovrhdot.VI[通气]/.DELTA.PaCO2 [动脉 PCO2] 显着高于 CO2 吸入。运动期间 pH 值振荡的幅度降低。呼吸和pH循环之间的相位关系(.phi.)的变化虽然从第二次呼吸开始就显着，但不被认为是导致.ovrhdot.VI增加的原因；变化的方向与之前发现的增加.ovrhdot.VI 的方向相反。吸气持续时间 (ti)、呼气持续时间 (te)、.ovrhdot.VI 和 dpH/dt.dwnarw.max 在第三次运动呼吸时发生显着变化。在运动的瞬时（前 10 次呼吸）期间，te 和 dpH/dt.dwnarw.max 之间存在显着的线性关系。这种关系在整个锻炼过程中一直保持着。 .ovrhdot.VI 和 dph/dt.dwnarw.max 在瞬态期间也呈线性相关，但在整个运动过程中，这种关系并不成立。 dpH/dt.dwnarw.max 与 CO2 产生 (.ovrhdot.VCO2) 相关，这支持了 pH 振荡下降斜率是 .ovrhdot.VCO2 函数的预测。 dpH/dt.dwnarw.max(dpCO2/dt.dwnarw.max) 是运动中潜在的体液信号，可以完全解释 te 的缩短。由于在 dpH/.dwnarw.max 没有变化的情况下，.ovrhdot.VI 出现后期上升（由于潮气量 VT 的增加），因此认为 dpH/dt.dwnarw.max 不太可能是运动期间存在的唯一体液信号。
The effect of electrically induced exercise on the respiratory oscillation of arterial pH was studied in chloralose-anesthetized dogs with spinal cord trasnsection at T[thoracic]8/9 (dermatome level T6/7). Respiratory oscillations of arterial pH (presumed to be due to oscillations of arterial PCO2[CO2 partial pressure]) were sensed with a fast-responding electrode in 1 carotid artery. Breath-by-breath estimates of the maximum rate of change of pH of the downstroke of the pH oscillation (dpH/dt.dwnarw.max) were obtained by differentiating the pH signal. The ventilatory response to exercise could not be explained on the basis of sensitivity to CO2; the .DELTA..ovrhdot.VI[ventilation]/.DELTA.PaCO2 [arterial PCO2] was significantly greater for execise than for CO2 inhalation. The amplitude of the pH oscillations decreased during exercise. The change in the phase relationship (.phi.) between respiratory and pH cycles, although significant from the 2nd breath onwards, was not thought to be responsible for the increased .ovrhdot.VI; the direction of the change was opposite that previously found to increase .ovrhdot.VI. Inspiratory duration (ti), expiratory duration (te), .ovrhdot.VI and the dpH/dt.dwnarw.max changed significantly by the 3rd breath of exercise. A significantly linear relationship was obtained between te and dpH/dt.dwnarw.max during the on-transient (first 10 breaths) of exercise. This relationship was maintained throughout exercise. .ovrhdot.VI and dph/dt.dwnarw.max were also linearly related during the on-transient, although the same relationship did not hold true throughout exercise. The dpH/dt.dwnarw.max was related to CO2 production (.ovrhdot.VCO2), lending support to the prediction that the slope of the downstroke of the pH oscillation is a function of .ovrhdot.VCO2. The dpH/dt.dwnarw.max(dpCO2/dt.dwnarw.max) is a potential humoral signal in exercise and could account totally for the shortening of te. Since there was a late rise in .ovrhdot.VI (due to an increase in tidal volume, VT) in the absence of a change in dpH/.dwnarw.max, it was considered unlikely that the dpH/dt.dwnarw.max was the only humoral signal present during exercise.