SPECT/CT MIBG Imaging Is Crucial in the Follow-up of the Patients With High-Risk Neuroblastoma
SPECT/CT MIBG Imaging Is Crucial in the Follow-up of the Patients With High-Risk Neuroblastoma
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DOI：
10.1097/rlu.0000000000001984
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发表时间：
2018-04-01
影响因子：
10.6
通讯作者：
Zhuang, Hongming
中科院分区：
文献类型：
--
作者：
Liu, Bin;Servaes, Sabah;Zhuang, Hongming
背景 I-123 放射性标记间碘苄胍 (I-123-MIBG) 平面全身成像通常用于神经母细胞瘤的随访评估。近年来，集成低剂量 CT 的 SPECT (SPECT/CT) 变得越来越容易使用。我们研究了 SPECT/CT 在检测残留和复发性神经母细胞瘤方面比平面成像具有多少额外的诊断价值。方法对 147 名已知高危神经母细胞瘤患者进行的总共 170 次平面 I-123-MIBG 成像扫描以及 SPECT/CT 随访扫描进行回顾性分析。将平面图像上 I-123-MIBG 摄取增加的区域与 SPECT/CT 上的结果进行比较。结果 在 61% 的研究中，全身平面图像和 SPECT/CT 图像得出相同的结果。然而，在 39% 的情况下，SPECT/CT 图像提供了额外的信息。 结论 在高危神经母细胞瘤患者的随访中，SPECT/CT 可以显着改善平面成像解释并影响患者管理。
Background Planar whole-body imaging with I-123-radiolabeled metaiodobenzylguanidine (I-123-MIBG) is routinely used in the follow-up evaluation of neuroblastoma. In recent years, SPECT with integrated low-dose CT (SPECT/CT) has become more accessible. We investigated how much SPECT/CT can have additional diagnostic value over planar imaging in detection of residual and recurrent neuroblastoma.Methods A total of 170 planar I-123-MIBG imaging scans with SPECT/CT follow-up scans performed in 147 patients with known high-risk neuroblastoma were retrospectively analyzed. Regions of increased I-123-MIBG uptake on planar images and the findings on SPECT/CT were compared.Results In 61% of the studies, the whole-body planar images and SPECT/CT images yielded the same result. In 39% of the time, however, SPECT/CT images provided additional information.Conclusions In the follow-up of patients with high-risk neuroblastoma, SPECT/CT can significantly improve planar imaging interpretation and impact patient management.