Selenium-mediated inhibition of mouse mammary tumorigenesis.
Selenium-mediated inhibition of mouse mammary tumorigenesis.
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硒介导的小鼠乳腺肿瘤发生的抑制。
DOI：
10.1016/0304-3835(80)90009-9
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发表时间：
1980
期刊：
影响因子：
9.7
通讯作者：
Shepherd,F
中科院分区：
文献类型：
--
作者：
Medina,D;Shepherd,F
本文用两种系统研究了硒对小鼠乳腺肿瘤发生的影响。BALB cfC 3 H（MuMTV-S阳性）在饮用水中给予2 ppm和6ppm硒并保持为繁殖小鼠，其乳腺肿瘤的发生率（分别为48%和12%）显著低于未处理的对照小鼠（82%）。硒在4 ppm的抑制肿瘤产生的能力，只有1的4 preneoplastic生长线保持在BALB c（MuMTV-S阴性）小鼠。2、4和6ppm硒对BALB c小鼠皮下移植的原发性乳腺肿瘤的生长率无影响。硒抑制乳腺肿瘤的发生，而不干扰正常的生殖功能和体重增加。
The effects of selenium on mouse mammary tumorigenesis were examined in 2 systems. BALB cfC3H (MuMTV-S positive) given 2 and 6 ppm selenium in the drinking water and maintained as breeding mice, had significantly lower incidences of mammary tumors (48% and 12%, respectively) than untreated control mice (82%). Selenium at 4 ppm inhibited the tumor-producing capabilities of only 1 of 4 preneoplastic outgrowth lines maintained in BALB c (MuMTV-S negative) mice. Selenium at 2, 4 and 6 ppm had no effect on the growth rate of primary mammary tumors transplanted subcutaneously in BALB c mice. Selenium inhibited mammary tumorigenesis without interference of normal reproductive function and weight gain.