Lamin in inflammation and aging.
Lamin in inflammation and aging.
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DOI：
10.1016/j.ceb.2016.03.004
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发表时间：
2016-06
影响因子：
7.5
通讯作者：
Zheng Y
中科院分区：
文献类型：
--
作者：
Tran JR;Chen H;Zheng X;Zheng Y
衰老的特征在于组织功能的逐渐丧失以及对损伤和疾病的易感性增加。许多与年龄相关的病理表现出炎症成分，这导致了衰老至少部分是由某种形式的炎症引起的推测。然而，炎症是否真的是衰老的原因，或者是衰老过程的结果尚不清楚。最近使用果蝇的研究揭示了一种机制，即随着年龄的增长，脂肪体中层粘连蛋白B的逐渐丢失会引发全身炎症。这种炎症反应扰乱了邻近肠道组织的局部免疫反应并导致增生。在这里，我们将讨论连接核纤层蛋白衰老和炎症的文献。
Aging is characterized by a progressive loss of tissue function and an increased susceptibility to injury and disease. Many age-associated pathologies manifest an inflammatory component, and this has led to the speculation that aging is at least in part caused by some form of inflammation. However, whether or not inflammation is truly a cause of aging, or is a consequence of the aging process is unknown. Recent work using Drosophila has uncovered a mechanism where the progressive loss of lamin-B in the fat body upon aging triggers systemic inflammation. This inflammatory response perturbs the local immune response of the neighboring gut tissue and leads to hyperplasia. Here, we will discuss the literature connecting lamins to aging and inflammation.