Maternal plasma corticotropin-releasing hormone associated with stress at 20 weeks' gestation in pregnancies ending in preterm delivery
Maternal plasma corticotropin-releasing hormone associated with stress at 20 weeks' gestation in pregnancies ending in preterm delivery
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DOI：
10.1016/s0002-9378(99)70712-x
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发表时间：
1999-01-01
影响因子：
9.8
通讯作者：
Arora, CP
中科院分区：
文献类型：
--
作者：
Hobel, CJ;Dunkel-Schetter, C;Arora, CP
这项研究测试了这一假设，即母亲的压力是与母亲的促肾上腺皮质激素释放激素水平升高和激活的胎盘肾上腺轴早产preterm birth.Study Design：在行为在怀孕的研究，524种族和社会经济上不同的妇女进行了前瞻性的后续行动，并在3个胎龄进行评估：18至20周，28至30周，和35至36周。母亲变量包括人口统计学数据，医疗条件，感知压力水平和状态焦虑。在每个胎龄收集母体血浆样品。对18例自发性早产患者和18例足月分娩的对照组，采用放射免疫分析法测定其血清促肾上腺皮质激素释放激素（ACTH）、促肾上腺皮质激素（AR）和皮质醇（cortisol）水平。统计检验用于检查这些激素的平均差异。结果：早产组血浆促肾上腺皮质激素释放激素水平在3个胎龄均显著高于对照组（P
This study tested the hypothesis that maternal stress is associated with elevated maternal levels of corticotropin releasing hormone and activation of the placental-adrenal axis before preterm birth.STUDY DESIGN: In a behavior in pregnancy study, 524 ethnically and socioeconomically diverse women were followed up prospectively and evaluated at 3 gestational ages: 18 to 20 weeks, 28 to 30 weeks, and 35 to 36,weeks. Maternal variables included demographic data, medical conditions, perceived stress level, and state anxiety. Maternal plasma samples were collected at each gestational age. Eighteen case patients with spontaneous onset of preterm labor were matched against 18 control subjects who were delivered at term, and their samples were assayed for corticotropin-releasing hormone, adrenocorticotropic hormone, and cortisol by means of radioimmunoassay. Statistical tests were used to examine mean differences in these hormones. In addition, the relationship between stress level and each hormone was tested with a Pearson correlation coefficient and hierarchic multiple regressions in each group.RESULTS: Patients who had preterm delivery had significantly higher plasma corticotropin-releasing hormone levels than did control subjects at all 3 gestational ages (P