PATTERNS OF ETHANOL-INDUCED CELL-DEATH IN THE DEVELOPING NERVOUS-SYSTEM OF MICE - NEURAL FOLD STATES THROUGH THE TIME OF ANTERIOR NEURAL-TUBE CLOSURE
PATTERNS OF ETHANOL-INDUCED CELL-DEATH IN THE DEVELOPING NERVOUS-SYSTEM OF MICE - NEURAL FOLD STATES THROUGH THE TIME OF ANTERIOR NEURAL-TUBE CLOSURE
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DOI：
10.1016/0736-5748(92)90016-s
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发表时间：
1992-08-01
影响因子：
1.8
通讯作者：
SULIK, KK
中科院分区：
文献类型：
--
作者：
KOTCH, LE;SULIK, KK
急性母体乙醇给药（2.9 g/kg）后12 h，小鼠胚胎的活体染色和常规组织学分析表明，选定的神经元细胞群被杀死。在处理时，胚胎具有5-15个体节对，对应于在受精后第四周期间在人类中发生的发育阶段;即当存在神经褶皱并且神经管融合开始时。具有6-26个体节对（直至前神经孔关闭阶段）的胚胎中受影响的细胞群位于菱脑翼板和基板、耳基板/囊泡以及鳃上基板、嗅基板区域的离散位置。和三叉神经节。这些细胞群的脆弱性，乙醇诱导的细胞死亡的潜在基础进行了讨论。我们对乙醇诱导的中枢神经系统损伤范围的理解取决于进一步定义中枢神经系统发育各个阶段的乙醇敏感细胞群。
Vital staining and routine histological analyses of mouse embryos 12 h after acute maternal ethanol administration (2.9 g/kg) illustrated that selected neuronal cell populations are killed. At the time of treatment, embryos had 5-15 somite pairs, corresponding to the developmental stages occurring in humans during the fourth week of post-fertilization; i.e. when neural folds are present and neural tube fusion begins. Affected cell populations in embryos having 6-26 somite pairs (up to the stage of anterior neuropore closure) were in discrete locations in the alar and basal plates of the rhombencephalon, in the otic placode/vesicle, and in the regions of the epibranchial placodes, olfactory placodes and trigeminal ganglion. The potential basis for the vulnerability of these cell populations to ethanol-induced cell death is discussed. Our understanding of the scope of ethanol-induced CNS damage is dependent upon further defining ethanol-sensitive cell populations at all stages of CNS development.