Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study.
Increased levels of ascorbic acid in the cerebrospinal fluid of cognitively intact elderly patients with major depression: a preliminary study.
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DOI：
10.1038/s41598-017-03836-0
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发表时间：
2017-06-14
影响因子：
4.6
通讯作者：
Pomara N
中科院分区：
文献类型：
--
作者：
Hashimoto K;Ishima T;Sato Y;Bruno D;Nierenberg J;Marmar CR;Zetterberg H;Blennow K;Pomara N
老年人的重度抑郁症（MDD）是痴呆症的一个危险因素，但确切的生物学基础仍然未知，阻碍了寻找新的生物标志物和治疗方法。在这项研究中，我们对认知功能完整的老年MDD患者（N = 28）和年龄和性别匹配的健康对照（N = 18）的脑脊液（CSF）进行代谢组学分析。测量了177种物质的CSF水平，而288种物质低于检测限。只有抗坏血酸有显著差异，MDD组基线水平较高。基线时，MDD患者CSF抗坏血酸水平与临床变量之间无相关性。在3年随访时，两组之间的CSF抗坏血酸水平没有差异。在所有受试者中，CSF抗坏血酸和CSF淀粉样蛋白-β 42水平之间呈负相关。然而，抗坏血酸和其他生物标志物（例如，淀粉样蛋白-β 40，总的和磷酸化的tau蛋白）。这项初步研究表明，在运输和/或释放的抗坏血酸的异常可能在晚年抑郁症的发病机制中发挥作用。
Major depressive disorder (MDD) in the elderly is a risk factor for dementia, but the precise biological basis remains unknown, hampering the search for novel biomarkers and treatments. In this study, we performed metabolomics analysis of cerebrospinal fluid (CSF) from cognitively intact elderly patients (N = 28) with MDD and age- and gender-matched healthy controls (N = 18). The CSF levels of 177 substances were measured, while 288 substances were below the detection limit. Only ascorbic acid was significantly different, with higher levels in the MDD group at baseline. There were no correlations between CSF ascorbic acid levels and clinical variables in MDD patients at baseline. At the 3-year follow-up, there was no difference of CSF ascorbic acid levels between the two groups. There was a negative correlation between CSF ascorbic acid and CSF amyloid-β42 levels in all subjects. However, there were no correlations between ascorbic acid and other biomarkers (e.g., amyloid-β40, total and phosphorylated tau protein). This preliminary study suggests that abnormalities in the transport and/or release of ascorbic acid might play a role in the pathogenesis of late-life depression.