Increased MAPK activity and MKP-1 overexpression in human gastric adenocarcinoma
Increased MAPK activity and MKP-1 overexpression in human gastric adenocarcinoma
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DOI：
10.1006/bbrc.1998.9256
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发表时间：
1998-09-08
影响因子：
3.1
通讯作者：
Yang, YC
中科院分区：
文献类型：
--
作者：
Bang, YJ;Kwon, JH;Yang, YC
丝裂原活化蛋白激酶（MAPK）在人类肿瘤的发生发展过程中起着重要的调控作用。为了了解MAPK在人胃组织癌变过程中的作用，我们检测了人胃腺癌组织中MAPK水平的变化，发现MAPK活性的增加伴随着丝裂原活化蛋白激酶磷酸酶-1（MKP-1）的过度表达，提示导致MAPK活化和MKP诱导的信号通路-1表达与人胃腺癌发生相关，（C）1998学术出版社。
Mitogen-activated protein kinase (MAPK) has been known to play a critical role in the regulation of the carcinogenesis in human cancers. In an effort to understand the functional role of the MAPK in the carcinogenesis of human gastric tissues, we examined the changes of MAPK levels in human gastric adenocarcinoma, We found that increased MAPK activity was accompanied by overexpression of mitogen-activated protein kinase phosphatase-l (MKP-1), suggesting that signaling pathways leading to the activation of MAPK and the induction of MKP-1 expression are associated with carcinogenesis of human gastric adenocarcinoma, (C) 1998 Academic Press.