Successful chemotherapy in experimental leishmaniasis is influenced by the polarity of the T cell response before treatment.
Successful chemotherapy in experimental leishmaniasis is influenced by the polarity of the T cell response before treatment.
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实验性利什曼病的成功化疗受到治疗前 T 细胞反应极性的影响。
DOI：
10.1093/infdis/173.4.979
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Farrell,JP
中科院分区：
文献类型：
--
作者：
Nabors,GS;Farrell,JP
宿主因素对利什曼病化疗成功的影响知之甚少。虽然成功治疗的患者将从迟发型超敏反应（DTH）阴性转化为DTH阳性状态，但治疗前宿主免疫状态的重要性仍在很大程度上未被探索。在实验性鼠皮肤利什曼病中，发现在药物治疗开始之前朝向Th 2细胞因子谱的极化增加导致治疗后复发频率增加。然而，当用抗利什曼原虫药物葡萄糖酸锑钠治疗时，大于50%的已建立的利什曼原虫感染的小鼠被治愈，而当动物在治疗前用抗干扰素-γ抗体预处理以使反应转向Th 2细胞因子模式时，小于10%的小鼠被治愈。随着药物治疗的成功，发现细胞因子谱从Th 2型转变为Th 1型，并观察到对再感染的抵抗力。
Little is known about the influence of host factors on successful chemotherapy in leishmaniasis. Although successfully treated patients will convert from a delayed-type hypersensitivity (DTH)-negative to a DTH-positive state, the importance of the immune status of the host before treatment remains largely unexplored. In experimental murine cutaneous leishmaniasis, it was found that increased polarization towards a Th2 cytokine profile before the onset of drug therapy leads to an increased frequency of relapse after treatment. Whereas >50% of mice with establishedLeishmania majorinfections were cured when treated with the antileishmanial drug sodium stibogluconate, <10% of mice were cured when the animals had been pretreated with anti-interferon-γ antibody to polarize the response toward a Th2 cytokine pattern before therapy. With successful drug therapy, cytokine profiles were found to switch from a Th2 to Th1 pattern, and resistance to reinfection was observed.