QUANTITATIVE RELATION BETWEEN SITES OF ATRIAL IMPULSE ORIGIN AND CYCLE LENGTH
QUANTITATIVE RELATION BETWEEN SITES OF ATRIAL IMPULSE ORIGIN AND CYCLE LENGTH
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DOI：
10.1152/ajpheart.1983.245.5.h781
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发表时间：
1983-01-01
影响因子：
--
通讯作者：
WYLDS, AC
中科院分区：
文献类型：
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作者：
BOINEAU, JP;SCHUESSLER, RB;WYLDS, AC
先前已经描述了多中心起源的心房冲动从网站广泛分布在右心房，以及这些网站的起源和周期长度（CL）之间的内在联系，这种关系进行了定量研究。在132只戊巴比妥钠或枸橼酸芬太尼麻醉的狗中，从360个紧密定位的电极记录心房激动序列图，并确定在心率80和240之间（CL在750和250之间）的冲动起源的位置。心脏神经刺激和激动剂-拮抗剂输注用于产生CL和冲动起源的变化。结果表明，冲动起源和CL之间的网站显着相关性。这些部位与窦房结（SN）和窦房结部位相关，在高于和低于SN占主导地位的心率时可预测地和一致地控制冲动启动。这种关系可用于指定心房起搏器层级的解剖功能模型，并量化不同心房区域对特定药理学和生理学干预的反应。
Having previously described the multicentric origin of the atrial impulse from sites widely distributed over the right atrium as well as an intrinsic link between these sites of origin and cycle length (CL), a quantitative study of this relationship was undertaken. In 132 dogs anesthetized with pentobarbital sodium or fentanyl citrate, atrial activation sequence maps were recorded from 360 closely positioned electrodes and determined locations of impulse origin at heart rates between 80 and 240 (CL between 750 and 250). Cardiac nerve stimulation and agonist-antagonist infusion were used to produce changes in CL and impulse origin. Results demonstrate a significant correlation between site of impulse origin and CL. These sites, associated with both the sinus node (SN) and extranodal sites, function predictably and consistently controlling impulse initiation at heart rates above and below rates at which the SN predominates. This relationship can be used to specify an anatomic-functional model of atrial pacemaker hierarchy and to quantitate the response of different atrial regions to specific pharmacological and physiological interventions.